DegronMD

Uniprot ID: Q96PC5

Source protein: Melanoma inhibitory activity protein 2

Source gene: MIA2

Class: LIG_APCC_ABBA_1

Location: 141:146

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.895

ASA_SCORE: 107.2167

COIL: 0.7942

CONS_SCORE: 0.7927

DSS_SCORE: 0.5177

HELIX: 0.0625

FCONS_SCORE: 1.1774

RIG_SCORE: 0.8102

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D149V	TCGA-50-5944	LUAD	TCGA	IYPYEE	LIG_APCC_ABBA_1	0.25
p.S153C	TCGA-90-7769	LUSC	TCGA	IYPYEE	LIG_APCC_ABBA_1	0.1389
p.K151T	TCGA-CA-6718	COAD	TCGA	IYPYEE	LIG_APCC_ABBA_1	0.3056
p.S152F	TCGA-D3-A1Q6	SKCM	TCGA	IYPYEE	LIG_APCC_ABBA_1	0.1667
p.Y155H	TCGA-D8-A1XK	BRCA	TCGA	IYPYEE	LIG_APCC_ABBA_1	0.0833
p.P143L	TCGA-DA-A3F8	SKCM	TCGA	IYPYEE	LIG_APCC_ABBA_1	0.6471
p.S152Y	TCGA-F5-6814	READ	TCGA	IYPYEE	LIG_APCC_ABBA_1	0.1667
p.D149Y	TCGA-VS-A8EK	CESC	TCGA	IYPYEE	LIG_APCC_ABBA_1	0.25
p.Y154H	DO4749	BRCA	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.1111
p.D148Y	DO51623	CESC	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.2778
p.K150T	DO7801	COAD	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.2222
p.I140M	DO229010	COCA	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.3056
p.I140M	DO229013	COCA	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.3056
p.I140M	DO229016	COCA	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.3056
p.I140M	DO229003	COCA	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.3056
p.I140M	DO229005	COCA	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.3056
p.I140M	DO228941	LICA	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.3056
p.I140M	DO229047	LICA	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.3056
p.D148V	DO24379	LUAD	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.2778
p.N133K	DO231078	LUSC	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.1111
p.S152C	DO26822	LUSC	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.1667
p.E155D	DO222546	MELA	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.0833
p.E149K	DO222632	MELA	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.25
p.G134S	DO227759	PBCA	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.1389
p.S151Y	DO36556	READ	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.3056
p.P142L	DO37418	SKCM	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.7582
p.S151F	DO37450	SKCM	ICGC	IYPYEE	LIG_APCC_ABBA_1	0.3056
p.I141V	SIDM00767	Small Cell Lung Carcinoma	GDSC	IYPYEE	LIG_APCC_ABBA_1	0.5965
p.I141V	ACH-001136	Lung Cancer	CCLE	IYPYEE	LIG_APCC_ABBA_1	0.5965
p.I141V	NCI-H187	lung	COSMIC	IYPYEE	LIG_APCC_ABBA_1	0.5965
p.E156A	ACH-002710	Sarcoma	CCLE	IYPYEE	LIG_APCC_ABBA_1	0.0556
p.S136A	LN-18	central_nervous_system	COSMIC	IYPYEE	LIG_APCC_ABBA_1	0.1944
p.S141N	NCI-H716	large_intestine	COSMIC	IYPYEE	LIG_APCC_ABBA_1	0.7069
p.S146N	NCI-H716	large_intestine	COSMIC	IYPYEE	LIG_APCC_ABBA_1	0.7069
p.S141A	LN-18	central_nervous_system	COSMIC	IYPYEE	LIG_APCC_ABBA_1	0.7588

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IYPYEE

Degron related mutations and impact score

Drug responses associated with MIA2 mutations

All proteins holding degron of IYPYEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PC5	Melanoma inhibitory activity protein 2	LIG_APCC_ABBA_1	141:146	IYPYEE	APC,CDC20,FZR1	0.895	More...