DegronMD

Uniprot ID: Q92736

Source protein: Ryanodine receptor 2

Source gene: RYR2

Class: DEG_APCC_DBOX_1

Location: 2025:2033

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8251

ASA_SCORE: 44.8333

COIL: 0.0544

CONS_SCORE: 0.4847

DSS_SCORE: 0.1936

HELIX: 0.9352

FCONS_SCORE: 1.2782

RIG_SCORE: 0.8352

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2028C	TCGA-12-0819	GBM	TCGA	IRGRLLSLV	DEG_APCC_DBOX_1	0.719
p.R2028C	TCGA-19-1390	GBM	TCGA	IRGRLLSLV	DEG_APCC_DBOX_1	0.719
p.L2023F	TCGA-2G-AAHP	TGCT	TCGA	IRGRLLSLV	DEG_APCC_DBOX_1	0.2778
p.R2028S	TCGA-49-AARE	LUAD	TCGA	IRGRLLSLV	DEG_APCC_DBOX_1	0.6316
p.G2027W	TCGA-CN-A63U	HNSC	TCGA	IRGRLLSLV	DEG_APCC_DBOX_1	0.6714
p.R2028H	TCGA-D5-6930	COAD	TCGA	IRGRLLSLV	DEG_APCC_DBOX_1	0.7133
p.R2028H	SIDM00317	Kidney Carcinoma	GDSC	IRGRLLSLV	DEG_APCC_DBOX_1	0.7133
p.R2028H	ACH-000171	Kidney Cancer	CCLE	IRGRLLSLV	DEG_APCC_DBOX_1	0.7133
p.R2028H	VMRC-RCZ	kidney	COSMIC	IRGRLLSLV	DEG_APCC_DBOX_1	0.7133
p.S2016F	TCGA-L9-A8F4	LUAD	TCGA	IRGRLLSLV	DEG_APCC_DBOX_1	0.0833
p.S2039Y	DO48366	BLCA	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	0.1667
p.S2039Y	DO218944	LUAD	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	0.1667
p.S2039Y	DO26025	LUAD	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	0.1667
p.E2029Q	DO6251	CESC	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	0.6744
p.Y2022C	DO233821	GACA	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	0.25
p.D2035E	DO233941	GACA	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	0.2778
p.A2028S	DO229031	LICA	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	0.7588
p.T2041S	DO45321	LUAD	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	0.2222
p.K2024M	DO48581	PAEN	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	0.3056
p.E2033Q	DO37916	SKCM	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	0.6744
p.L2029Q	SIDM00507	Other Solid Cancers	GDSC	IRGRLLSLV	DEG_APCC_DBOX_1	0.7765
p.L2029Q	ACH-001490	Lung Cancer	CCLE	IRGRLLSLV	DEG_APCC_DBOX_1	0.7765
p.L2029Q	COR-L321	NS	COSMIC	IRGRLLSLV	DEG_APCC_DBOX_1	0.7765
p.K2042Q	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	IRGRLLSLV	DEG_APCC_DBOX_1	0.1944
p.K2042Q	ACH-000627	Lung Cancer	CCLE	IRGRLLSLV	DEG_APCC_DBOX_1	0.1944
p.K2042Q	LCLC-103H	lung	COSMIC	IRGRLLSLV	DEG_APCC_DBOX_1	0.1944
p.K2037R	HCC2998	large_intestine	COSMIC	IRGRLLSLV	DEG_APCC_DBOX_1	0.2222
p.K2026Q	LCLC-103H	lung	COSMIC	IRGRLLSLV	DEG_APCC_DBOX_1	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRGRLLSLV

Degron related mutations and impact score

Drug responses associated with RYR2 mutations

All proteins holding degron of IRGRLLSLV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92736	Ryanodine receptor 2	DEG_APCC_DBOX_1	2025:2033	IRGRLLSLV	APC,CDC20,FZR1	0.8251	More...