DegronMD - Q92736(RYR2)

GO - Biological processes (BP): calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; calcium-mediated signaling [GO:0019722]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cardiac muscle contraction [GO:0060048]; cardiac muscle hypertrophy [GO:0003300]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular calcium ion homeostasis [GO:0006874]; cellular response to caffeine [GO:0071313]; cellular response to epinephrine stimulus [GO:0071872]; detection of calcium ion [GO:0005513]; embryonic heart tube morphogenesis [GO:0003143]; establishment of protein localization to endoplasmic reticulum [GO:0072599]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; positive regulation of ATPase-coupled calcium transmembrane transporter activity [GO:1901896]; positive regulation of heart rate [GO:0010460]; positive regulation of sequestering of calcium ion [GO:0051284]; positive regulation of the force of heart contraction [GO:0098735]; Purkinje myocyte to ventricular cardiac muscle cell signaling [GO:0086029]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of AV node cell action potential [GO:0098904]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate [GO:0002027]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to caffeine [GO:0031000]; response to hypoxia [GO:0001666]; response to muscle activity [GO:0014850]; response to muscle stretch [GO:0035994]; response to redox state [GO:0051775]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; type B pancreatic cell apoptotic process [GO:0097050]; ventricular cardiac muscle cell action potential [GO:0086005] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R2028C	TCGA-12-0819	GBM	TCGA	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.719
p.R2028C	TCGA-19-1390	GBM	TCGA	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.719
p.P3522T	TCGA-17-Z030	LUAD	TCGA	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.1667
p.D3540N	TCGA-22-5479	LUSC	TCGA	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.1389
p.D3540N	TCGA-VS-A94X	CESC	TCGA	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.1389
p.L2023F	TCGA-2G-AAHP	TGCT	TCGA	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation rewiring degron network	0.2778
p.A3523T	TCGA-39-5022	LUSC	TCGA	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.1944
p.R2028S	TCGA-49-AARE	LUAD	TCGA	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.6316
p.Y3531C	TCGA-77-6842	LUSC	TCGA	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation altering degron motif	0.7087
p.Y3531C	DO27413	LUSC	ICGC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation altering degron motif	0.7087
p.A3529V	TCGA-AP-A1DV	UCEC	TCGA	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation altering degron motif	0.5825
p.R3537S	TCGA-B0-5702	KIRC	TCGA	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.2222
p.E3520D	TCGA-BS-A0TA	UCEC	TCGA	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.1111
p.D3521G	TCGA-BS-A0UJ	UCEC	TCGA	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.1389
p.G2027W	TCGA-CN-A63U	HNSC	TCGA	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.6714
p.R3537K	TCGA-D3-A3MU	SKCM	TCGA	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.2222
p.R2028H	TCGA-D5-6930	COAD	TCGA	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.7133
p.R2028H	SIDM00317	Kidney Carcinoma	GDSC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.7133
p.R2028H	ACH-000171	Kidney Cancer	CCLE	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.7133
p.R2028H	VMRC-RCZ	kidney	COSMIC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.7133
p.S3542L	TCGA-FD-A6TD	BLCA	TCGA	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.0833
p.S3542L	DO49757	BLCA	ICGC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.0833
p.S2016F	TCGA-L9-A8F4	LUAD	TCGA	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation rewiring degron network	0.0833
p.D3539Y	TCGA-N8-A4PN	UCS	TCGA	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.1667
p.S2039Y	DO48366	BLCA	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation rewiring degron network	0.1667
p.S2039Y	DO218944	LUAD	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation rewiring degron network	0.1667
p.S2039Y	DO26025	LUAD	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation rewiring degron network	0.1667
p.D3524N	DO51632	CESC	ICGC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.2222
p.D3524N	DO27287	LUSC	ICGC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.2222
p.E2029Q	DO6251	CESC	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.6744
p.Y2022C	DO233821	GACA	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation rewiring degron network	0.25
p.D2035E	DO233941	GACA	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation rewiring degron network	0.2778
p.R3521S	DO18192	KIRC	ICGC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.1389
p.A2028S	DO229031	LICA	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.7588
p.T2041S	DO45321	LUAD	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation substituting flanking lysine	0.2222
p.P3528S	DO222708	MELA	ICGC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation altering degron motif	0.6752
p.E3520K	DO222843	MELA	ICGC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.1111
p.R3534I	DO46657	PAAD	ICGC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.3056
p.R3534I	DO42713	UCEC	ICGC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.3056
p.K2024M	DO48581	PAEN	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation rewiring degron network	0.3056
p.T3531M	DO233492	PRAD	ICGC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation altering degron motif	0.7423
p.T3531M	D-247MG	central nervous system	COSMIC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation altering degron motif	0.7423
p.R3521K	DO47337	SKCM	ICGC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.1389
p.E2033Q	DO37916	SKCM	ICGC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.6744
p.F3543S	DO38324	STAD	ICGC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.0556
p.E3529D	DO43041	UCEC	ICGC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation altering degron motif	0.6758
p.D3537Y	DO42793	UCEC	ICGC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.2222
p.L2029Q	SIDM00507	Other Solid Cancers	GDSC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.7765
p.L2029Q	ACH-001490	Lung Cancer	CCLE	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.7765
p.L2029Q	COR-L321	NS	COSMIC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.7765
p.K2042Q	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation substituting flanking lysine	0.1944
p.K2042Q	ACH-000627	Lung Cancer	CCLE	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation substituting flanking lysine	0.1944
p.K2042Q	LCLC-103H	lung	COSMIC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation substituting flanking lysine	0.1944
p.L3519M	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.0833
p.L3519M	HCC-827	lung	COSMIC	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.0833
p.T3541A	ACH-001786	Colon/Colorectal Cancer	CCLE	MALYKD	LIG_APCC_ABBA_1	3528:3533	Mutation rewiring degron network	0.1111
p.K2037R	HCC2998	large intestine	COSMIC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation rewiring degron network	0.2222
p.K2026Q	LCLC-103H	lung	COSMIC	IRGRLLSLV	DEG_APCC_DBOX_1	2025:2033	Mutation altering degron motif	0.6944

Kaplan plot for RYR2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RYR2

UniProt ID: Q92736

Entrez ID: 6262

Protein name: Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RYR2 in