DegronMD

Uniprot ID: Q92736

Source protein: Ryanodine receptor 2

Source gene: RYR2

Class: LIG_APCC_ABBA_1

Location: 3528:3533

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5024

ASA_SCORE: 51.5

COIL: 0.1572

CONS_SCORE: 0.429

DSS_SCORE: 0.3532

HELIX: 0.6193

FCONS_SCORE: 1.2927

RIG_SCORE: 0.8291

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3522T	TCGA-17-Z030	LUAD	TCGA	MALYKD	LIG_APCC_ABBA_1	0.1667
p.D3540N	TCGA-22-5479	LUSC	TCGA	MALYKD	LIG_APCC_ABBA_1	0.1389
p.D3540N	TCGA-VS-A94X	CESC	TCGA	MALYKD	LIG_APCC_ABBA_1	0.1389
p.A3523T	TCGA-39-5022	LUSC	TCGA	MALYKD	LIG_APCC_ABBA_1	0.1944
p.Y3531C	TCGA-77-6842	LUSC	TCGA	MALYKD	LIG_APCC_ABBA_1	0.7087
p.Y3531C	DO27413	LUSC	ICGC	MALYKD	LIG_APCC_ABBA_1	0.7087
p.A3529V	TCGA-AP-A1DV	UCEC	TCGA	MALYKD	LIG_APCC_ABBA_1	0.5825
p.R3537S	TCGA-B0-5702	KIRC	TCGA	MALYKD	LIG_APCC_ABBA_1	0.2222
p.E3520D	TCGA-BS-A0TA	UCEC	TCGA	MALYKD	LIG_APCC_ABBA_1	0.1111
p.D3521G	TCGA-BS-A0UJ	UCEC	TCGA	MALYKD	LIG_APCC_ABBA_1	0.1389
p.R3537K	TCGA-D3-A3MU	SKCM	TCGA	MALYKD	LIG_APCC_ABBA_1	0.2222
p.S3542L	TCGA-FD-A6TD	BLCA	TCGA	MALYKD	LIG_APCC_ABBA_1	0.0833
p.S3542L	DO49757	BLCA	ICGC	MALYKD	LIG_APCC_ABBA_1	0.0833
p.D3539Y	TCGA-N8-A4PN	UCS	TCGA	MALYKD	LIG_APCC_ABBA_1	0.1667
p.D3524N	DO51632	CESC	ICGC	MALYKD	LIG_APCC_ABBA_1	0.2222
p.D3524N	DO27287	LUSC	ICGC	MALYKD	LIG_APCC_ABBA_1	0.2222
p.R3521S	DO18192	KIRC	ICGC	MALYKD	LIG_APCC_ABBA_1	0.1389
p.P3528S	DO222708	MELA	ICGC	MALYKD	LIG_APCC_ABBA_1	0.6752
p.E3520K	DO222843	MELA	ICGC	MALYKD	LIG_APCC_ABBA_1	0.1111
p.R3534I	DO46657	PAAD	ICGC	MALYKD	LIG_APCC_ABBA_1	0.3056
p.R3534I	DO42713	UCEC	ICGC	MALYKD	LIG_APCC_ABBA_1	0.3056
p.T3531M	DO233492	PRAD	ICGC	MALYKD	LIG_APCC_ABBA_1	0.7423
p.T3531M	D-247MG	central_nervous_system	COSMIC	MALYKD	LIG_APCC_ABBA_1	0.7423
p.R3521K	DO47337	SKCM	ICGC	MALYKD	LIG_APCC_ABBA_1	0.1389
p.F3543S	DO38324	STAD	ICGC	MALYKD	LIG_APCC_ABBA_1	0.0556
p.E3529D	DO43041	UCEC	ICGC	MALYKD	LIG_APCC_ABBA_1	0.6758
p.D3537Y	DO42793	UCEC	ICGC	MALYKD	LIG_APCC_ABBA_1	0.2222
p.L3519M	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	MALYKD	LIG_APCC_ABBA_1	0.0833
p.L3519M	HCC-827	lung	COSMIC	MALYKD	LIG_APCC_ABBA_1	0.0833
p.T3541A	ACH-001786	Colon/Colorectal Cancer	CCLE	MALYKD	LIG_APCC_ABBA_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MALYKD

Degron related mutations and impact score

Drug responses associated with RYR2 mutations

All proteins holding degron of MALYKD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92736	Ryanodine receptor 2	LIG_APCC_ABBA_1	3528:3533	MALYKD	APC,CDC20,FZR1	0.5024	More...