DegronMD

Uniprot ID: Q8N423

Source protein: Leukocyte immunoglobulin-like receptor subfamily B member 2

Source gene: LILRB2

Class: DEG_SCF_FBW7_1

Location: 321:328

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 52.25

COIL: 0.7745

CONS_SCORE: 0.3312

DSS_SCORE: 0.3484

HELIX: 0.0321

FCONS_SCORE: 0.684

RIG_SCORE: 0.7665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V335M	TCGA-BF-A5EO	SKCM	TCGA	IRGTPFIS	DEG_SCF_FBW7_1	0.1389
p.V335M	DO219450	SKCM	ICGC	IRGTPFIS	DEG_SCF_FBW7_1	0.1389
p.P333T	TCGA-EB-A299	SKCM	TCGA	IRGTPFIS	DEG_SCF_FBW7_1	0.1944
p.P333T	DO37794	SKCM	ICGC	IRGTPFIS	DEG_SCF_FBW7_1	0.1944
p.G323C	TCGA-HT-7609	LGG	TCGA	IRGTPFIS	DEG_SCF_FBW7_1	0.6489
p.G323C	DO22732	LGG	ICGC	IRGTPFIS	DEG_SCF_FBW7_1	0.6489
p.R322H	DO230993	LUSC	ICGC	IRGTPFIS	DEG_SCF_FBW7_1	0.7133
p.P325S	DO229453	SKCA	ICGC	IRGTPFIS	DEG_SCF_FBW7_1	0.6752
p.I317T	SIDM00915	Small Cell Lung Carcinoma	GDSC	IRGTPFIS	DEG_SCF_FBW7_1	0.2222
p.I327M	SIDM00963	Breast Carcinoma	GDSC	IRGTPFIS	DEG_SCF_FBW7_1	0.6507
p.I327M	ACH-000927	Breast Cancer	CCLE	IRGTPFIS	DEG_SCF_FBW7_1	0.6507
p.I327M	BT-474	breast	COSMIC	IRGTPFIS	DEG_SCF_FBW7_1	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N423	Leukocyte immunoglobulin-like receptor subfamily B member 2	DEG_SCF_FBW7_1	321:328	IRGTPFIS	FBXW7	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons