DegronMD - Q8N423(LILRB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L15M	TCGA-AA-3984	COAD	TCGA	MTPIVT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0833
p.L15M	DO9002	COAD	ICGC	MTPIVT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0833
p.Q442K	TCGA-AJ-A3IA	UCEC	TCGA	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.25
p.Q442K	DO231951	LICA	ICGC	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.25
p.Q442K	DO43082	UCEC	ICGC	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.25
p.V335M	TCGA-BF-A5EO	SKCM	TCGA	IRGTPFIS	DEG_SCF_FBW7_1	321:328	Mutation rewiring degron network	0.1389
p.V335M	DO219450	SKCM	ICGC	IRGTPFIS	DEG_SCF_FBW7_1	321:328	Mutation rewiring degron network	0.1389
p.P333T	TCGA-EB-A299	SKCM	TCGA	IRGTPFIS	DEG_SCF_FBW7_1	321:328	Mutation rewiring degron network	0.1944
p.P333T	DO37794	SKCM	ICGC	IRGTPFIS	DEG_SCF_FBW7_1	321:328	Mutation rewiring degron network	0.1944
p.G323C	TCGA-HT-7609	LGG	TCGA	IRGTPFIS	DEG_SCF_FBW7_1	321:328	Mutation altering degron motif	0.6489
p.G323C	DO22732	LGG	ICGC	IRGTPFIS	DEG_SCF_FBW7_1	321:328	Mutation altering degron motif	0.6489
p.G431S	TCGA-VS-A958	CESC	TCGA	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.3056
p.G431S	DO51639	CESC	ICGC	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.3056
p.V5I	DO225181	BRCA	ICGC	MTPIVT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.5965
p.P3H	DO227802	COCA	ICGC	MTPIVT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7694
p.T445I	DO50443	ESAD	ICGC	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.1667
p.T430S	DO230525	LUSC	ICGC	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.2778
p.R322H	DO230993	LUSC	ICGC	IRGTPFIS	DEG_SCF_FBW7_1	321:328	Mutation altering degron motif	0.7133
p.GP438GS	DO222632	MELA	ICGC	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation altering degron motif	0.6993
p.P446L	DO229130	NKTL	ICGC	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.1389
p.P325S	DO229453	SKCA	ICGC	IRGTPFIS	DEG_SCF_FBW7_1	321:328	Mutation altering degron motif	0.6752
p.P446S	DO37474	SKCM	ICGC	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.1389
p.I317T	SIDM00915	Small Cell Lung Carcinoma	GDSC	IRGTPFIS	DEG_SCF_FBW7_1	321:328	Mutation rewiring degron network	0.2222
p.S449L	SIDM01164	Glioma	GDSC	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.0556
p.S449L	ACH-000883	Brain Cancer	CCLE	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.0556
p.I327M	SIDM00963	Breast Carcinoma	GDSC	IRGTPFIS	DEG_SCF_FBW7_1	321:328	Mutation altering degron motif	0.6507
p.I327M	ACH-000927	Breast Cancer	CCLE	IRGTPFIS	DEG_SCF_FBW7_1	321:328	Mutation altering degron motif	0.6507
p.I327M	BT-474	breast	COSMIC	IRGTPFIS	DEG_SCF_FBW7_1	321:328	Mutation altering degron motif	0.6507
p.T6I	SIDM01470	Acute Myeloid Leukemia	GDSC	MTPIVT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7078
p.T6I	ACH-000387	Leukemia	CCLE	MTPIVT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7078
p.P428R	ACH-000206	Lymphoma	CCLE	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.2222
p.G448V	ACH-000610	Lung Cancer	CCLE	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.0833
p.G431C	ACH-000674	Gastric Cancer	CCLE	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.3056
p.P432S	ACH-001530	Endometrial/Uterine Cancer	CCLE	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation altering degron motif	0.6752
p.P16S	KMH-2	thyroid	COSMIC	MTPIVT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0556
p.P16H	MDA-MB-361	breast	COSMIC	MTPIVT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0556
p.T9N	SK-MEL-28	skin	COSMIC	MTPIVT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.25
p.A440S	PWR-1E	prostate	COSMIC	PISTPGPE	DEG_SCF_FBW7_2	432:439	Mutation rewiring degron network	0.3056

Kaplan plot for LILRB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LILRB2

UniProt ID: Q8N423

Entrez ID: 10288

Protein name: Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LILRB2 in