DegronMD

Uniprot ID: Q8N423

Source protein: Leukocyte immunoglobulin-like receptor subfamily B member 2

Source gene: LILRB2

Class: DEG_SCF_FBW7_2

Location: 432:439

E3 ligase: FBXW7

DEGRON score: 0.9156

ASA_SCORE: 80.6

COIL: 0.9305

CONS_SCORE: 0.4198

DSS_SCORE: 0.8703

HELIX: 0.0236

FCONS_SCORE: 1.0304

RIG_SCORE: 0.5218

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q442K	TCGA-AJ-A3IA	UCEC	TCGA	PISTPGPE	DEG_SCF_FBW7_2	0.25
p.Q442K	DO231951	LICA	ICGC	PISTPGPE	DEG_SCF_FBW7_2	0.25
p.Q442K	DO43082	UCEC	ICGC	PISTPGPE	DEG_SCF_FBW7_2	0.25
p.G431S	TCGA-VS-A958	CESC	TCGA	PISTPGPE	DEG_SCF_FBW7_2	0.3056
p.G431S	DO51639	CESC	ICGC	PISTPGPE	DEG_SCF_FBW7_2	0.3056
p.T445I	DO50443	ESAD	ICGC	PISTPGPE	DEG_SCF_FBW7_2	0.1667
p.T430S	DO230525	LUSC	ICGC	PISTPGPE	DEG_SCF_FBW7_2	0.2778
p.GP438GS	DO222632	MELA	ICGC	PISTPGPE	DEG_SCF_FBW7_2	0.6993
p.P446L	DO229130	NKTL	ICGC	PISTPGPE	DEG_SCF_FBW7_2	0.1389
p.P446S	DO37474	SKCM	ICGC	PISTPGPE	DEG_SCF_FBW7_2	0.1389
p.S449L	SIDM01164	Glioma	GDSC	PISTPGPE	DEG_SCF_FBW7_2	0.0556
p.S449L	ACH-000883	Brain Cancer	CCLE	PISTPGPE	DEG_SCF_FBW7_2	0.0556
p.P428R	ACH-000206	Lymphoma	CCLE	PISTPGPE	DEG_SCF_FBW7_2	0.2222
p.G448V	ACH-000610	Lung Cancer	CCLE	PISTPGPE	DEG_SCF_FBW7_2	0.0833
p.G431C	ACH-000674	Gastric Cancer	CCLE	PISTPGPE	DEG_SCF_FBW7_2	0.3056
p.P432S	ACH-001530	Endometrial/Uterine Cancer	CCLE	PISTPGPE	DEG_SCF_FBW7_2	0.6752
p.A440S	PWR-1E	prostate	COSMIC	PISTPGPE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N423	Leukocyte immunoglobulin-like receptor subfamily B member 2	DEG_SCF_FBW7_2	432:439	PISTPGPE	FBXW7	0.9156	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons