DegronMD

Uniprot ID: Q8N423

Source protein: Leukocyte immunoglobulin-like receptor subfamily B member 2

Source gene: LILRB2

Class: DEG_SCF_FBW7_1

Location: 1:6

E3 ligase: FBXW7

DEGRON score: 0.8164

ASA_SCORE: 53.2667

COIL: 0.4982

CONS_SCORE: 0.5808

DSS_SCORE: 0.4407

HELIX: 0.4752

FCONS_SCORE: 1.1313

RIG_SCORE: 0.9011

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L15M	TCGA-AA-3984	COAD	TCGA	MTPIVT	DEG_SCF_FBW7_1	0.0833
p.L15M	DO9002	COAD	ICGC	MTPIVT	DEG_SCF_FBW7_1	0.0833
p.V5I	DO225181	BRCA	ICGC	MTPIVT	DEG_SCF_FBW7_1	0.5965
p.P3H	DO227802	COCA	ICGC	MTPIVT	DEG_SCF_FBW7_1	0.7694
p.T6I	SIDM01470	Acute Myeloid Leukemia	GDSC	MTPIVT	DEG_SCF_FBW7_1	0.7078
p.T6I	ACH-000387	Leukemia	CCLE	MTPIVT	DEG_SCF_FBW7_1	0.7078
p.P16S	KMH-2	thyroid	COSMIC	MTPIVT	DEG_SCF_FBW7_1	0.0556
p.P16H	MDA-MB-361	breast	COSMIC	MTPIVT	DEG_SCF_FBW7_1	0.0556
p.T9N	SK-MEL-28	skin	COSMIC	MTPIVT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N423	Leukocyte immunoglobulin-like receptor subfamily B member 2	DEG_SCF_FBW7_1	1:6	MTPIVT	FBXW7	0.8164	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons