DegronMD

Uniprot ID: Q8TCU5

Source protein: Glutamate receptor ionotropic, NMDA 3A

Source gene: GRIN3A

Class: LIG_APCC_ABBA_1

Location: 1040:1045

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9351

ASA_SCORE: 106.6167

COIL: 0.7658

CONS_SCORE: 0.3969

DSS_SCORE: 0.5804

HELIX: 0.0912

FCONS_SCORE: 0.8372

RIG_SCORE: 0.7745

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1045N	TCGA-91-6829	LUAD	TCGA	IRIHQD	LIG_APCC_ABBA_1	0.6932
p.D1045N	DO23564	LUAD	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.6932
p.S1030T	TCGA-CD-8529	STAD	TCGA	IRIHQD	LIG_APCC_ABBA_1	0.0556
p.S1030T	DO47753	STAD	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.0556
p.E1032D	TCGA-CM-4743	COAD	TCGA	IRIHQD	LIG_APCC_ABBA_1	0.1111
p.E1032D	DO8103	COAD	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.1111
p.P1050L	TCGA-F7-A624	HNSC	TCGA	IRIHQD	LIG_APCC_ABBA_1	0.1944
p.P1050L	DO44440	HNSC	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.1944
p.P1047S	DO1083	BRCA	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.2778
p.R1041Q	DO230334	COCA	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.6218
p.R1041Q	DO229010	COCA	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.6218
p.R1041Q	DO229013	COCA	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.6218
p.R1041Q	DO229003	COCA	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.6218
p.R1041Q	DO229505	LAML	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.6218
p.R1041Q	DO230659	LAML	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.6218
p.R1041Q	DO231140	LAML	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.6218
p.R1041Q	DO228941	LICA	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.6218
p.R1041Q	DO228947	LICA	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.6218
p.R1041Q	DO229047	LICA	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.6218
p.R1041Q	DO231155	LUSC	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.6218
p.L1048F	DO220886	MELA	ICGC	IRIHQD	LIG_APCC_ABBA_1	0.25
p.E1033K	SIDM00057	Neuroblastoma	GDSC	IRIHQD	LIG_APCC_ABBA_1	0.1389
p.E1033K	ACH-000676	Brain Cancer	CCLE	IRIHQD	LIG_APCC_ABBA_1	0.1389
p.E1033K	ACH-002389	Neuroblastoma	CCLE	IRIHQD	LIG_APCC_ABBA_1	0.1389
p.E1033K	ACN	autonomic_ganglia	COSMIC	IRIHQD	LIG_APCC_ABBA_1	0.1389
p.G1034R	ACH-000465	Skin Cancer	CCLE	IRIHQD	LIG_APCC_ABBA_1	0.1667
p.G1034R	SK-MEL-1	skin	COSMIC	IRIHQD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	LIG_APCC_ABBA_1	1040:1045	IRIHQD	APC,CDC20,FZR1	0.9351	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRIHQD

Degron related mutations and impact score

Drug responses associated with GRIN3A mutations

All proteins holding degron of IRIHQD