DegronMD - Q8TCU5(GRIN3A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1059Q	TCGA-76-6191	GBM	TCGA	RRRELPALR	DEG_APCC_DBOX_1	1051:1059	Mutation altering degron motif	0.6218
p.R1059Q	TCGA-AA-3966	COAD	TCGA	RRRELPALR	DEG_APCC_DBOX_1	1051:1059	Mutation altering degron motif	0.6218
p.R1059Q	DO10068	COAD	ICGC	RRRELPALR	DEG_APCC_DBOX_1	1051:1059	Mutation altering degron motif	0.6218
p.D1045N	TCGA-91-6829	LUAD	TCGA	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation altering degron motif	0.6932
p.D1045N	DO23564	LUAD	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation altering degron motif	0.6932
p.R1059W	TCGA-BR-8360	STAD	TCGA	RRRELPALR	DEG_APCC_DBOX_1	1051:1059	Mutation altering degron motif	0.7523
p.R1059W	DO47745	STAD	ICGC	RRRELPALR	DEG_APCC_DBOX_1	1051:1059	Mutation altering degron motif	0.7523
p.S1030T	TCGA-CD-8529	STAD	TCGA	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation rewiring degron network	0.0556
p.S1030T	DO47753	STAD	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation rewiring degron network	0.0556
p.E1032D	TCGA-CM-4743	COAD	TCGA	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation rewiring degron network	0.1111
p.E1032D	DO8103	COAD	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation rewiring degron network	0.1111
p.A1065E	TCGA-CN-6994	HNSC	TCGA	RRRELPALR	DEG_APCC_DBOX_1	1051:1059	Mutation rewiring degron network	0.1667
p.A1065E	DO15398	HNSC	ICGC	RRRELPALR	DEG_APCC_DBOX_1	1051:1059	Mutation rewiring degron network	0.1667
p.P1050L	TCGA-F7-A624	HNSC	TCGA	RRRELPALR	DEG_APCC_DBOX_1	1051:1059	Mutation rewiring degron network	0.3056
p.P1050L	TCGA-F7-A624	HNSC	TCGA	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation rewiring degron network	0.1944
p.P1050L	DO44440	HNSC	ICGC	RRRELPALR	DEG_APCC_DBOX_1	1051:1059	Mutation rewiring degron network	0.3056
p.P1050L	DO44440	HNSC	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation rewiring degron network	0.1944
p.E1054K	TCGA-QQ-A5V9	SARC	TCGA	RRRELPALR	DEG_APCC_DBOX_1	1051:1059	Mutation altering degron motif	0.591
p.E1054K	DO220245	SARC	ICGC	RRRELPALR	DEG_APCC_DBOX_1	1051:1059	Mutation altering degron motif	0.591
p.P1047S	DO1083	BRCA	ICGC	RRRELPALR	DEG_APCC_DBOX_1	1051:1059	Mutation rewiring degron network	0.2222
p.P1047S	DO1083	BRCA	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation rewiring degron network	0.2778
p.R1041Q	DO230334	COCA	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation altering degron motif	0.6218
p.R1041Q	DO229010	COCA	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation altering degron motif	0.6218
p.R1041Q	DO229013	COCA	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation altering degron motif	0.6218
p.R1041Q	DO229003	COCA	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation altering degron motif	0.6218
p.R1041Q	DO229505	LAML	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation altering degron motif	0.6218
p.R1041Q	DO230659	LAML	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation altering degron motif	0.6218
p.R1041Q	DO231140	LAML	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation altering degron motif	0.6218
p.R1041Q	DO228941	LICA	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation altering degron motif	0.6218
p.R1041Q	DO228947	LICA	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation altering degron motif	0.6218
p.R1041Q	DO229047	LICA	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation altering degron motif	0.6218
p.R1041Q	DO231155	LUSC	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation altering degron motif	0.6218
p.L1048F	DO220886	MELA	ICGC	RRRELPALR	DEG_APCC_DBOX_1	1051:1059	Mutation rewiring degron network	0.25
p.L1048F	DO220886	MELA	ICGC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation rewiring degron network	0.25
p.L1055F	DO36556	READ	ICGC	RRRELPALR	DEG_APCC_DBOX_1	1051:1059	Mutation altering degron motif	0.6981
p.E1033K	SIDM00057	Neuroblastoma	GDSC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation rewiring degron network	0.1389
p.E1033K	ACH-000676	Brain Cancer	CCLE	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation rewiring degron network	0.1389
p.E1033K	ACH-002389	Neuroblastoma	CCLE	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation rewiring degron network	0.1389
p.E1033K	ACN	autonomic ganglia	COSMIC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation rewiring degron network	0.1389
p.G1034R	ACH-000465	Skin Cancer	CCLE	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation rewiring degron network	0.1667
p.G1034R	SK-MEL-1	skin	COSMIC	IRIHQD	LIG_APCC_ABBA_1	1040:1045	Mutation rewiring degron network	0.1667

Kaplan plot for GRIN3A in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRIN3A

UniProt ID: Q8TCU5

Entrez ID: 116443

Protein name: Glutamate receptor ionotropic, NMDA 3A (GluN3A) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for GRIN3A in