DegronMD

Uniprot ID: Q8TCU5

Source protein: Glutamate receptor ionotropic, NMDA 3A

Source gene: GRIN3A

Class: DEG_APCC_DBOX_1

Location: 1051:1059

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9967

ASA_SCORE: 108.5111

COIL: 0.8229

CONS_SCORE: 0.5713

DSS_SCORE: 0.6223

HELIX: 0.129

FCONS_SCORE: 1.231

RIG_SCORE: 0.7137

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1059Q	TCGA-76-6191	GBM	TCGA	RRRELPALR	DEG_APCC_DBOX_1	0.6218
p.R1059Q	TCGA-AA-3966	COAD	TCGA	RRRELPALR	DEG_APCC_DBOX_1	0.6218
p.R1059Q	DO10068	COAD	ICGC	RRRELPALR	DEG_APCC_DBOX_1	0.6218
p.R1059W	TCGA-BR-8360	STAD	TCGA	RRRELPALR	DEG_APCC_DBOX_1	0.7523
p.R1059W	DO47745	STAD	ICGC	RRRELPALR	DEG_APCC_DBOX_1	0.7523
p.A1065E	TCGA-CN-6994	HNSC	TCGA	RRRELPALR	DEG_APCC_DBOX_1	0.1667
p.A1065E	DO15398	HNSC	ICGC	RRRELPALR	DEG_APCC_DBOX_1	0.1667
p.P1050L	TCGA-F7-A624	HNSC	TCGA	RRRELPALR	DEG_APCC_DBOX_1	0.3056
p.P1050L	DO44440	HNSC	ICGC	RRRELPALR	DEG_APCC_DBOX_1	0.3056
p.E1054K	TCGA-QQ-A5V9	SARC	TCGA	RRRELPALR	DEG_APCC_DBOX_1	0.591
p.E1054K	DO220245	SARC	ICGC	RRRELPALR	DEG_APCC_DBOX_1	0.591
p.P1047S	DO1083	BRCA	ICGC	RRRELPALR	DEG_APCC_DBOX_1	0.2222
p.L1048F	DO220886	MELA	ICGC	RRRELPALR	DEG_APCC_DBOX_1	0.25
p.L1055F	DO36556	READ	ICGC	RRRELPALR	DEG_APCC_DBOX_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	DEG_APCC_DBOX_1	1051:1059	RRRELPALR	APC,CDC20,FZR1	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons