DegronMD

Uniprot ID: Q9H6W3

Source protein: Ribosomal oxygenase 1

Source gene: RIOX1

Class: DEG_APCC_DBOX_1

Location: 39:47

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9606

ASA_SCORE: 105.0778

COIL: 0.3838

CONS_SCORE: 0.29

DSS_SCORE: 0.4686

HELIX: 0.5967

FCONS_SCORE: 1.0575

RIG_SCORE: 0.7644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S48F	SIDM00194	Colorectal Carcinoma	GDSC	IRKQLRSVV	DEG_APCC_DBOX_1	0.75
p.S48F	SNU-61	large_intestine	COSMIC	IRKQLRSVV	DEG_APCC_DBOX_1	0.75
p.L32M	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	IRKQLRSVV	DEG_APCC_DBOX_1	0.1389
p.L32M	SIDM00969	Ovarian Carcinoma	GDSC	IRKQLRSVV	DEG_APCC_DBOX_1	0.1389
p.L32M	SIDM00656	Burkitt's Lymphoma	GDSC	IRKQLRSVV	DEG_APCC_DBOX_1	0.1389
p.L32M	SIDM00741	Small Cell Lung Carcinoma	GDSC	IRKQLRSVV	DEG_APCC_DBOX_1	0.1389
p.L32M	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	IRKQLRSVV	DEG_APCC_DBOX_1	0.1389
p.L32M	SIDM00694	Other Solid Cancers	GDSC	IRKQLRSVV	DEG_APCC_DBOX_1	0.1389
p.L32M	SIDM00254	Neuroblastoma	GDSC	IRKQLRSVV	DEG_APCC_DBOX_1	0.1389
p.L32M	SIDM00844	Burkitt's Lymphoma	GDSC	IRKQLRSVV	DEG_APCC_DBOX_1	0.1389
p.L32M	SIDM00256	Neuroblastoma	GDSC	IRKQLRSVV	DEG_APCC_DBOX_1	0.1389
p.L32M	SIDM00760	Small Cell Lung Carcinoma	GDSC	IRKQLRSVV	DEG_APCC_DBOX_1	0.1389
p.L32M	SIDM00641	Burkitt's Lymphoma	GDSC	IRKQLRSVV	DEG_APCC_DBOX_1	0.1389
p.L32M	SIDM01686	Chronic Myelogenous Leukemia	GDSC	IRKQLRSVV	DEG_APCC_DBOX_1	0.1389
p.R54S	SIDM00457	Plasma Cell Myeloma	GDSC	IRKQLRSVV	DEG_APCC_DBOX_1	0.1389
p.R54S	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	IRKQLRSVV	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H6W3	Ribosomal oxygenase 1	DEG_APCC_DBOX_1	39:47	IRKQLRSVV	APC,CDC20,FZR1	0.9606	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons