DegronMD

Uniprot ID: Q86UY5

Source protein: Protein FAM83A

Source gene: FAM83A

Class: DEG_APCC_DBOX_1

Location: 10:18

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.732

ASA_SCORE: 87.1333

COIL: 0.2619

CONS_SCORE: 0.8334

DSS_SCORE: 0.3955

HELIX: 0.6833

FCONS_SCORE: 1.1886

RIG_SCORE: 0.7601

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R13H	TCGA-DU-6392	LGG	TCGA	IRKRLEDVK	DEG_APCC_DBOX_1	0.7133
p.R13H	DO22237	LGG	ICGC	IRKRLEDVK	DEG_APCC_DBOX_1	0.7133
p.R26M	TCGA-EO-A3KX	UCEC	TCGA	IRKRLEDVK	DEG_APCC_DBOX_1	0.1111
p.R26M	DO219774	UCEC	ICGC	IRKRLEDVK	DEG_APCC_DBOX_1	0.1111
p.R23W	DO46542	OV	ICGC	IRKRLEDVK	DEG_APCC_DBOX_1	0.1944
p.R26W	SIDM00989	Bladder Carcinoma	GDSC	IRKRLEDVK	DEG_APCC_DBOX_1	0.1111
p.R26W	ACH-000802	Bladder Cancer	CCLE	IRKRLEDVK	DEG_APCC_DBOX_1	0.1111
p.R26W	BFTC-905	urinary_tract	COSMIC	IRKRLEDVK	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UY5	Protein FAM83A	DEG_APCC_DBOX_1	10:18	IRKRLEDVK	APC,CDC20,FZR1	0.732	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons