DegronMD

Uniprot ID: Q5T440

Source protein: Putative transferase CAF17, mitochondrial

Source gene: IBA57

Class: DEG_APCC_DBOX_1

Location: 275:283

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6175

ASA_SCORE: 62.4444

COIL: 0.2788

CONS_SCORE: 0.7042

DSS_SCORE: 0.1643

HELIX: 0.0202

FCONS_SCORE: 1.3168

RIG_SCORE: 0.8912

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V282F	TCGA-69-7978	LUAD	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	0.7068
p.R283W	TCGA-AA-A022	COAD	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	0.7523
p.R278H	TCGA-AX-A1CE	UCEC	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	0.7133
p.R278H	SIDM00217	Colorectal Carcinoma	GDSC	IRKRLFPVR	DEG_APCC_DBOX_1	0.7133
p.R278H	ACH-000999	Colon/Colorectal Cancer	CCLE	IRKRLFPVR	DEG_APCC_DBOX_1	0.7133
p.R278H	SNU-1040	large_intestine	COSMIC	IRKRLFPVR	DEG_APCC_DBOX_1	0.7133
p.R278C	TCGA-B5-A3FC	UCEC	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	0.719
p.R278C	TCGA-FI-A2D5	UCEC	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	0.719
p.R268H	TCGA-EO-A3AV	UCEC	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	0.1389
p.R268H	TCGA-HT-8564	LGG	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	0.1389
p.P289S	TCGA-FR-A7U9	SKCM	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	0.1667
p.R283Q	TCGA-WS-AB45	COAD	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	0.6218
p.L285W	SIDM01090	Colorectal Carcinoma	GDSC	IRKRLFPVR	DEG_APCC_DBOX_1	0.2778
p.L285W	ACH-000943	Colon/Colorectal Cancer	CCLE	IRKRLFPVR	DEG_APCC_DBOX_1	0.2778
p.L285W	RKO	large_intestine	COSMIC	IRKRLFPVR	DEG_APCC_DBOX_1	0.2778
p.G292A	SIDM00907	Burkitt's Lymphoma	GDSC	IRKRLFPVR	DEG_APCC_DBOX_1	0.0833
p.G292A	ACH-000440	Lymphoma	CCLE	IRKRLFPVR	DEG_APCC_DBOX_1	0.0833
p.G292A	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	IRKRLFPVR	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T440	Putative transferase CAF17, mitochondrial	DEG_APCC_DBOX_1	275:283	IRKRLFPVR	APC,CDC20,FZR1	0.6175	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons