DegronMD - Q5T440(IBA57)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G296C	TCGA-09-2044	OV	TCGA	ITPGAT	DEG_SCF_FBW7_1	293:298	Mutation altering degron motif	0.6489
p.V282F	TCGA-69-7978	LUAD	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7068
p.R283W	TCGA-AA-A022	COAD	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7523
p.T294I	TCGA-AP-A1DK	UCEC	TCGA	ITPGAT	DEG_SCF_FBW7_1	293:298	Mutation altering degron motif	0.7078
p.R278H	TCGA-AX-A1CE	UCEC	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7133
p.R278H	SIDM00217	Colorectal Carcinoma	GDSC	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7133
p.R278H	ACH-000999	Colon/Colorectal Cancer	CCLE	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7133
p.R278H	SNU-1040	large intestine	COSMIC	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7133
p.R278C	TCGA-B5-A3FC	UCEC	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.719
p.R278C	TCGA-FI-A2D5	UCEC	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.719
p.A302T	TCGA-EO-A22U	UCEC	TCGA	ITPGAT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.2222
p.R268H	TCGA-EO-A3AV	UCEC	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1389
p.R268H	TCGA-HT-8564	LGG	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1389
p.P289S	TCGA-FR-A7U9	SKCM	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1667
p.P289S	TCGA-FR-A7U9	SKCM	TCGA	ITPGAT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.2222
p.S303L	TCGA-UC-A7PD	CESC	TCGA	ITPGAT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.1944
p.R283Q	TCGA-WS-AB45	COAD	TCGA	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.6218
p.L285W	SIDM01090	Colorectal Carcinoma	GDSC	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.2778
p.L285W	SIDM01090	Colorectal Carcinoma	GDSC	ITPGAT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.1111
p.L285W	ACH-000943	Colon/Colorectal Cancer	CCLE	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.2778
p.L285W	ACH-000943	Colon/Colorectal Cancer	CCLE	ITPGAT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.1111
p.L285W	RKO	large intestine	COSMIC	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.2778
p.L285W	RKO	large intestine	COSMIC	ITPGAT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.1111
p.G292A	SIDM00907	Burkitt's Lymphoma	GDSC	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.0833
p.G292A	SIDM00907	Burkitt's Lymphoma	GDSC	ITPGAT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.3056
p.G292A	ACH-000440	Lymphoma	CCLE	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.0833
p.G292A	ACH-000440	Lymphoma	CCLE	ITPGAT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.3056
p.G292A	CA46	haematopoietic and lymphoid tissue	COSMIC	IRKRLFPVR	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.0833
p.G292A	CA46	haematopoietic and lymphoid tissue	COSMIC	ITPGAT	DEG_SCF_FBW7_1	293:298	Mutation rewiring degron network	0.3056

Kaplan plot for IBA57 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IBA57

UniProt ID: Q5T440

Entrez ID: 200205

Protein name: Putative transferase CAF17, mitochondrial (EC 2.1.-.-) (Iron-sulfur cluster assembly factor homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IBA57 in