DegronMD

Uniprot ID: Q5T440

Source protein: Putative transferase CAF17, mitochondrial

Source gene: IBA57

Class: DEG_SCF_FBW7_1

Location: 293:298

E3 ligase: FBXW7

DEGRON score: 0.7152

ASA_SCORE: 55.2833

COIL: 0.8533

CONS_SCORE: 0.2868

DSS_SCORE: 0.3513

HELIX: 0.0143

FCONS_SCORE: 0.7269

RIG_SCORE: 0.7522

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G296C	TCGA-09-2044	OV	TCGA	ITPGAT	DEG_SCF_FBW7_1	0.6489
p.T294I	TCGA-AP-A1DK	UCEC	TCGA	ITPGAT	DEG_SCF_FBW7_1	0.7078
p.A302T	TCGA-EO-A22U	UCEC	TCGA	ITPGAT	DEG_SCF_FBW7_1	0.2222
p.P289S	TCGA-FR-A7U9	SKCM	TCGA	ITPGAT	DEG_SCF_FBW7_1	0.2222
p.S303L	TCGA-UC-A7PD	CESC	TCGA	ITPGAT	DEG_SCF_FBW7_1	0.1944
p.L285W	SIDM01090	Colorectal Carcinoma	GDSC	ITPGAT	DEG_SCF_FBW7_1	0.1111
p.L285W	ACH-000943	Colon/Colorectal Cancer	CCLE	ITPGAT	DEG_SCF_FBW7_1	0.1111
p.L285W	RKO	large_intestine	COSMIC	ITPGAT	DEG_SCF_FBW7_1	0.1111
p.G292A	SIDM00907	Burkitt's Lymphoma	GDSC	ITPGAT	DEG_SCF_FBW7_1	0.3056
p.G292A	ACH-000440	Lymphoma	CCLE	ITPGAT	DEG_SCF_FBW7_1	0.3056
p.G292A	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	ITPGAT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T440	Putative transferase CAF17, mitochondrial	DEG_SCF_FBW7_1	293:298	ITPGAT	FBXW7	0.7152	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons