DegronMD

Uniprot ID: O75093

Source protein: Slit homolog 1 protein

Source gene: SLIT1

Class: DEG_APCC_DBOX_1

Location: 314:322

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6106

ASA_SCORE: 50.4556

COIL: 0.4992

CONS_SCORE: 0.6731

DSS_SCORE: 0.2928

HELIX: 0.2881

FCONS_SCORE: 1.3279

RIG_SCORE: 0.8149

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F329I	TCGA-50-5930	LUAD	TCGA	IRLELNGIK	DEG_APCC_DBOX_1	0.1389
p.F329I	DO25189	LUAD	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	0.1389
p.N319S	TCGA-AZ-4315	COAD	TCGA	IRLELNGIK	DEG_APCC_DBOX_1	0.5958
p.N319S	DO8842	COAD	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	0.5958
p.T312K	TCGA-EE-A2GN	SKCM	TCGA	IRLELNGIK	DEG_APCC_DBOX_1	0.2778
p.T312K	DO37896	SKCM	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	0.2778
p.E317K	TCGA-EE-A2MR	SKCM	TCGA	IRLELNGIK	DEG_APCC_DBOX_1	0.591
p.E317K	DO37819	SKCM	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	0.591
p.P325S	TCGA-FW-A3R5	SKCM	TCGA	IRLELNGIK	DEG_APCC_DBOX_1	0.25
p.P325S	DO37406	SKCM	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	0.25
p.R315H	TCGA-KO-8411	KICH	TCGA	IRLELNGIK	DEG_APCC_DBOX_1	0.8244
p.R315H	DO220577	KICH	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	0.8244
p.S323Y	DO233261	GACA	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	0.3056
p.P308T	DO228985	LICA	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	0.1667
p.A305D	DO229027	LICA	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	0.0833
p.P304Q	DO229038	LICA	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	0.0556
p.G327E	DO220881	MELA	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	0.1944
p.N319K	DO229216	THCA	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	0.5806
p.G320S	SIDM00487	Colorectal Carcinoma	GDSC	IRLELNGIK	DEG_APCC_DBOX_1	0.5882
p.G320S	ACH-000963	Colon/Colorectal Cancer	CCLE	IRLELNGIK	DEG_APCC_DBOX_1	0.5882
p.G320S	CCK-81	large_intestine	COSMIC	IRLELNGIK	DEG_APCC_DBOX_1	0.5882
p.P304S	ACH-000597	Rhabdoid	CCLE	IRLELNGIK	DEG_APCC_DBOX_1	0.0556
p.E309K	ACH-002039	Pancreatic Cancer	CCLE	IRLELNGIK	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75093	Slit homolog 1 protein	DEG_APCC_DBOX_1	314:322	IRLELNGIK	APC,CDC20,FZR1	0.6106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons