DegronMD - O75093(SLIT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F329I	TCGA-50-5930	LUAD	TCGA	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1389
p.F329I	DO25189	LUAD	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1389
p.N319S	TCGA-AZ-4315	COAD	TCGA	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.5958
p.N319S	DO8842	COAD	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.5958
p.T312K	TCGA-EE-A2GN	SKCM	TCGA	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.2778
p.T312K	DO37896	SKCM	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.2778
p.E317K	TCGA-EE-A2MR	SKCM	TCGA	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.591
p.E317K	DO37819	SKCM	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.591
p.P325S	TCGA-FW-A3R5	SKCM	TCGA	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.25
p.P325S	DO37406	SKCM	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.25
p.R315H	TCGA-KO-8411	KICH	TCGA	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.8244
p.R315H	DO220577	KICH	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.8244
p.L18R	DO50326	ESAD	ICGC	VRPELWLLL	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.8428
p.S323Y	DO233261	GACA	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.3056
p.P308T	DO228985	LICA	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1667
p.A305D	DO229027	LICA	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.0833
p.P304Q	DO229038	LICA	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.0556
p.G327E	DO220881	MELA	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1944
p.P5S	DO37861	SKCM	ICGC	VRPELWLLL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.0833
p.N319K	DO229216	THCA	ICGC	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.5806
p.A26T	DO229211	THCA	ICGC	VRPELWLLL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.2222
p.P16L	DO229242	THCA	ICGC	VRPELWLLL	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6471
p.G320S	SIDM00487	Colorectal Carcinoma	GDSC	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.5882
p.G320S	ACH-000963	Colon/Colorectal Cancer	CCLE	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.5882
p.G320S	CCK-81	large intestine	COSMIC	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation altering degron motif	0.5882
p.S9Y	ACH-000361	Liver Cancer	CCLE	VRPELWLLL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1944
p.P304S	ACH-000597	Rhabdoid	CCLE	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.0556
p.A24V	ACH-001061	Colon/Colorectal Cancer	CCLE	VRPELWLLL	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.2778
p.E309K	ACH-002039	Pancreatic Cancer	CCLE	IRLELNGIK	DEG_APCC_DBOX_1	314:322	Mutation rewiring degron network	0.1944

Kaplan plot for SLIT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLIT1

UniProt ID: O75093

Entrez ID: 6585

Protein name: Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLIT1 in