DegronMD

Uniprot ID: O75093

Source protein: Slit homolog 1 protein

Source gene: SLIT1

Class: DEG_APCC_DBOX_1

Location: 14:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9015

ASA_SCORE: 56.1444

COIL: 0.1258

CONS_SCORE: 0.3105

DSS_SCORE: 0.0874

HELIX: 0.8643

FCONS_SCORE: 1.2062

RIG_SCORE: 0.9451

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L18R	DO50326	ESAD	ICGC	VRPELWLLL	DEG_APCC_DBOX_1	0.8428
p.P5S	DO37861	SKCM	ICGC	VRPELWLLL	DEG_APCC_DBOX_1	0.0833
p.A26T	DO229211	THCA	ICGC	VRPELWLLL	DEG_APCC_DBOX_1	0.2222
p.P16L	DO229242	THCA	ICGC	VRPELWLLL	DEG_APCC_DBOX_1	0.6471
p.S9Y	ACH-000361	Liver Cancer	CCLE	VRPELWLLL	DEG_APCC_DBOX_1	0.1944
p.A24V	ACH-001061	Colon/Colorectal Cancer	CCLE	VRPELWLLL	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75093	Slit homolog 1 protein	DEG_APCC_DBOX_1	14:22	VRPELWLLL	APC,CDC20,FZR1	0.9015	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons