DegronMD

Uniprot ID: Q9H7P9

Source protein: Pleckstrin homology domain-containing family G member 2

Source gene: PLEKHG2

Class: DEG_APCC_DBOX_1

Location: 85:93

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8401

ASA_SCORE: 89.8889

COIL: 0.8851

CONS_SCORE: 0.4032

DSS_SCORE: 0.5704

HELIX: 0.054

FCONS_SCORE: 1.1082

RIG_SCORE: 0.6684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H88N	TCGA-85-A50Z	LUSC	TCGA	IRLHLSPVG	DEG_APCC_DBOX_1	0.6312
p.H88N	DO45462	LUSC	ICGC	IRLHLSPVG	DEG_APCC_DBOX_1	0.6312
p.A98T	DO233261	GACA	ICGC	IRLHLSPVG	DEG_APCC_DBOX_1	0.1944
p.G96V	DO229041	LICA	ICGC	IRLHLSPVG	DEG_APCC_DBOX_1	0.25
p.P91S	DO222521	MELA	ICGC	IRLHLSPVG	DEG_APCC_DBOX_1	0.5641
p.P91L	DO229456	SKCA	ICGC	IRLHLSPVG	DEG_APCC_DBOX_1	0.6471
p.R86C	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	IRLHLSPVG	DEG_APCC_DBOX_1	0.8301
p.V83L	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	IRLHLSPVG	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7P9	Pleckstrin homology domain-containing family G member 2	DEG_APCC_DBOX_1	85:93	IRLHLSPVG	APC,CDC20,FZR1	0.8401	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons