DegronMD - Q9H7P9(PLEKHG2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1213R	TCGA-50-7109	LUAD	TCGA	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation altering degron motif	0.7512
p.S1185I	TCGA-55-8506	LUAD	TCGA	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation rewiring degron network	0.0833
p.H88N	TCGA-85-A50Z	LUSC	TCGA	IRLHLSPVG	DEG_APCC_DBOX_1	85:93	Mutation altering degron motif	0.6312
p.H88N	DO45462	LUSC	ICGC	IRLHLSPVG	DEG_APCC_DBOX_1	85:93	Mutation altering degron motif	0.6312
p.P1262L	TCGA-A5-A0G1	UCEC	TCGA	LTPPHS	DEG_SCF_FBW7_1	1256:1261	Mutation rewiring degron network	0.3056
p.D1205Y	TCGA-A5-A0G2	UCEC	TCGA	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation rewiring degron network	0.1667
p.D1205Y	TCGA-A5-A0G2	UCEC	TCGA	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation rewiring degron network	0.2222
p.S1197L	TCGA-A5-A0GP	UCEC	TCGA	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation altering degron motif	0.6556
p.S1197L	TCGA-DF-A2KU	UCEC	TCGA	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation altering degron motif	0.6556
p.S1197L	TCGA-FW-A3R5	SKCM	TCGA	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation altering degron motif	0.6556
p.S1197L	SIDM00889	Cervical Carcinoma	GDSC	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation altering degron motif	0.6556
p.S1197L	ACH-001333	Cervical Cancer	CCLE	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation altering degron motif	0.6556
p.S1197L	C-33-A	cervix	COSMIC	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation altering degron motif	0.6556
p.S690F	TCGA-AB-2868	LAML	TCGA	VPNTPSLS	DEG_SCF_FBW7_1	677:684	Mutation rewiring degron network	0.1667
p.K1201T	TCGA-AD-6889	COAD	TCGA	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation substituting flanking lysine	0.2222
p.A1211S	TCGA-AG-3592	READ	TCGA	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation altering degron motif	0.6477
p.P1184S	TCGA-AL-3468	KIRP	TCGA	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation rewiring degron network	0.0556
p.G62R	TCGA-AO-A1KS	BRCA	TCGA	PGPTPACS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.2222
p.G62R	DO1547	BRCA	ICGC	PGPTPACS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.2222
p.A1211T	TCGA-AP-A059	UCEC	TCGA	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation altering degron motif	0.6028
p.L689I	TCGA-AP-A1DK	UCEC	TCGA	VPNTPSLS	DEG_SCF_FBW7_1	677:684	Mutation rewiring degron network	0.1944
p.T1212I	TCGA-AX-A06F	UCEC	TCGA	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation altering degron motif	0.7078
p.G976D	TCGA-AX-A3FX	UCEC	TCGA	PATTPLPE	DEG_SCF_FBW7_2	983:990	Mutation rewiring degron network	0.1389
p.G1225V	TCGA-B5-A1MW	UCEC	TCGA	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation rewiring degron network	0.3056
p.G1225V	TCGA-B5-A1MW	UCEC	TCGA	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation rewiring degron network	0.0833
p.D1222H	TCGA-CR-6472	HNSC	TCGA	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation rewiring degron network	0.2222
p.D1222H	TCGA-CR-6472	HNSC	TCGA	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation rewiring degron network	0.1667
p.I1223M	TCGA-D1-A103	UCEC	TCGA	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation rewiring degron network	0.25
p.I1223M	TCGA-D1-A103	UCEC	TCGA	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation rewiring degron network	0.1389
p.P1264S	TCGA-D6-6516	HNSC	TCGA	LTPPHS	DEG_SCF_FBW7_1	1256:1261	Mutation rewiring degron network	0.25
p.P1264L	TCGA-D6-6516	HNSC	TCGA	LTPPHS	DEG_SCF_FBW7_1	1256:1261	Mutation rewiring degron network	0.25
p.D974N	TCGA-DD-A4NO	LIHC	TCGA	PATTPLPE	DEG_SCF_FBW7_2	983:990	Mutation rewiring degron network	0.0833
p.D1188N	TCGA-EE-A180	SKCM	TCGA	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation rewiring degron network	0.1667
p.S1265F	TCGA-EE-A2MJ	SKCM	TCGA	LTPPHS	DEG_SCF_FBW7_1	1256:1261	Mutation blocking phosphorylation signal	0.6667
p.S1243F	TCGA-EE-A2MR	SKCM	TCGA	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation rewiring degron network	0.0556
p.T1257A	TCGA-EO-A22U	UCEC	TCGA	LTPPHS	DEG_SCF_FBW7_1	1256:1261	Mutation altering degron motif	0.825
p.E1216Q	TCGA-MV-A51V	BLCA	TCGA	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation altering degron motif	0.6744
p.G1242C	TCGA-X6-A7WC	SARC	TCGA	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation rewiring degron network	0.0833
p.P675H	TCGA-ZB-A966	THYM	TCGA	VPNTPSLS	DEG_SCF_FBW7_1	677:684	Mutation rewiring degron network	0.2778
p.E1187Q	DO474	BLCA	ICGC	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation rewiring degron network	0.1389
p.G1189R	DO225353	BRCA	ICGC	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation rewiring degron network	0.1944
p.P677A	DO229342	BTCA	ICGC	VPNTPSLS	DEG_SCF_FBW7_1	677:684	Mutation altering degron motif	0.7503
p.E996D	DO222884	COCA	ICGC	PATTPLPE	DEG_SCF_FBW7_2	983:990	Mutation rewiring degron network	0.1667
p.L1231V	DO234233	ESAD	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation altering degron motif	0.6765
p.E1210K	DO234191	ESAD	ICGC	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation altering degron motif	0.7022
p.A98T	DO233261	GACA	ICGC	IRLHLSPVG	DEG_APCC_DBOX_1	85:93	Mutation rewiring degron network	0.1944
p.L1192V	DO233667	GACA	ICGC	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation rewiring degron network	0.2778
p.A1271P	DO233947	GACA	ICGC	LTPPHS	DEG_SCF_FBW7_1	1256:1261	Mutation rewiring degron network	0.0556
p.D1193H	DO15870	HNSC	ICGC	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation rewiring degron network	0.3056
p.Q1229E	DO44450	HNSC	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation altering degron motif	0.6744
p.Q1229E	DO26442	LUSC	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation altering degron motif	0.6744
p.P1235L	DO15623	HNSC	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation rewiring degron network	0.2778
p.P1235S	DO15623	HNSC	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation rewiring degron network	0.2778
p.K1218R	DO229505	LAML	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation rewiring degron network	0.1111
p.K1218R	DO229505	LAML	ICGC	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation rewiring degron network	0.2778
p.G96V	DO229041	LICA	ICGC	IRLHLSPVG	DEG_APCC_DBOX_1	85:93	Mutation rewiring degron network	0.25
p.G1266R	DO52166	LIHC	ICGC	LTPPHS	DEG_SCF_FBW7_1	1256:1261	Mutation blocking phosphorylation signal	0.6389
p.P1184R	DO24487	LUAD	ICGC	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation rewiring degron network	0.0556
p.V1202F	DO231016	LUSC	ICGC	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation rewiring degron network	0.25
p.V1202F	DO231016	LUSC	ICGC	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation rewiring degron network	0.1389
p.E996K	DO52672	MALY	ICGC	PATTPLPE	DEG_SCF_FBW7_2	983:990	Mutation rewiring degron network	0.1667
p.P91S	DO222521	MELA	ICGC	IRLHLSPVG	DEG_APCC_DBOX_1	85:93	Mutation altering degron motif	0.5641
p.A65D	DO50733	ORCA	ICGC	PGPTPACS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.3056
p.A676T	DO31150	OV	ICGC	VPNTPSLS	DEG_SCF_FBW7_1	677:684	Mutation rewiring degron network	0.3056
p.R1221M	DO232761	PBCA	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation rewiring degron network	0.1944
p.R1221M	DO232761	PBCA	ICGC	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation rewiring degron network	0.1944
p.G1213C	DO220315	SARC	ICGC	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation altering degron motif	0.76
p.P91L	DO229456	SKCA	ICGC	IRLHLSPVG	DEG_APCC_DBOX_1	85:93	Mutation altering degron motif	0.6471
p.S1214F	DO37819	SKCM	ICGC	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation altering degron motif	0.7982
p.S1236F	DO38099	SKCM	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation rewiring degron network	0.25
p.V987I	DO51298	SKCM	ICGC	PATTPLPE	DEG_SCF_FBW7_2	983:990	Mutation altering degron motif	0.7076
p.P689L	DO219487	SKCM	ICGC	VPNTPSLS	DEG_SCF_FBW7_1	677:684	Mutation rewiring degron network	0.1944
p.E996A	DO38288	STAD	ICGC	PATTPLPE	DEG_SCF_FBW7_2	983:990	Mutation rewiring degron network	0.1667
p.A974T	DO43306	UCEC	ICGC	PATTPLPE	DEG_SCF_FBW7_2	983:990	Mutation rewiring degron network	0.0833
p.I1194M	DO42312	UCEC	ICGC	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation altering degron motif	0.7618
p.P669H	DO42280	UCEC	ICGC	VPNTPSLS	DEG_SCF_FBW7_1	677:684	Mutation rewiring degron network	0.1111
p.G1196V	DO42913	UCEC	ICGC	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation altering degron motif	0.7532
p.L1252M	DO42568	UCEC	ICGC	LTPPHS	DEG_SCF_FBW7_1	1256:1261	Mutation rewiring degron network	0.2222
p.H981R	DO41127	UCEC	ICGC	PATTPLPE	DEG_SCF_FBW7_2	983:990	Mutation rewiring degron network	0.2778
p.T1228A	DO43755	UCEC	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation altering degron motif	0.7139
p.P1233L	DO42472	UCEC	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation altering degron motif	0.7582
p.A1206T	SIDM01307	Colorectal Carcinoma	GDSC	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation rewiring degron network	0.1389
p.A1206T	SIDM01307	Colorectal Carcinoma	GDSC	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation rewiring degron network	0.25
p.H991R	SIDM00965	Small Cell Lung Carcinoma	GDSC	PATTPLPE	DEG_SCF_FBW7_2	983:990	Mutation rewiring degron network	0.3056
p.H991R	ACH-000800	Lung Cancer	CCLE	PATTPLPE	DEG_SCF_FBW7_2	983:990	Mutation rewiring degron network	0.3056
p.H991R	NCI-H446	lung	COSMIC	PATTPLPE	DEG_SCF_FBW7_2	983:990	Mutation rewiring degron network	0.3056
p.A74T	SIDM00383	Gastric Carcinoma	GDSC	PGPTPACS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.3056
p.P66T	SIDM00980	Gastric Carcinoma	GDSC	PGPTPACS	DEG_SCF_FBW7_1	66:73	Mutation altering degron motif	0.7031
p.P66T	ACH-000948	Gastric Cancer	CCLE	PGPTPACS	DEG_SCF_FBW7_1	66:73	Mutation altering degron motif	0.7031
p.R86C	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	IRLHLSPVG	DEG_APCC_DBOX_1	85:93	Mutation altering degron motif	0.8301
p.K1201E	ACH-000961	Endometrial/Uterine Cancer	CCLE	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation substituting flanking lysine	0.2222
p.E990K	ACH-000975	Lung Cancer	CCLE	PATTPLPE	DEG_SCF_FBW7_2	983:990	Mutation altering degron motif	0.7022
p.P1228S	MEL-JUSO	skin	COSMIC	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation altering degron motif	0.5641
p.V83L	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	IRLHLSPVG	DEG_APCC_DBOX_1	85:93	Mutation rewiring degron network	0.2778
p.V83L	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	PGPTPACS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.0556
p.K1218T	HCC2998	large intestine	COSMIC	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation rewiring degron network	0.1111
p.K1218T	HCC2998	large intestine	COSMIC	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation rewiring degron network	0.2778
p.I65T	SKN	soft tissue	COSMIC	PGPTPACS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.3056
p.F1221V	HT-115	large intestine	COSMIC	LSPTPVQT	DEG_SCF_FBW7_1	1226:1233	Mutation rewiring degron network	0.1944
p.F1221V	HT-115	large intestine	COSMIC	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation rewiring degron network	0.1944
p.L1185S	ONS-76	central nervous system	COSMIC	LTPSLE	DEG_SCF_FBW7_2	1194:1199	Mutation rewiring degron network	0.0833
p.E1214G	HEC-1	endometrium	COSMIC	PAATPLPE	DEG_SCF_FBW7_2	1209:1216	Mutation altering degron motif	0.7199
p.V66M	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	PGPTPACS	DEG_SCF_FBW7_1	66:73	Mutation altering degron motif	0.7208

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHG2

UniProt ID: Q9H7P9

Entrez ID: 64857

Protein name: Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHG2 in