DegronMD

Uniprot ID: Q9H7P9

Source protein: Pleckstrin homology domain-containing family G member 2

Source gene: PLEKHG2

Class: DEG_SCF_FBW7_2

Location: 1209:1216

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 74.175

COIL: 0.9268

CONS_SCORE: 0.3588

DSS_SCORE: 0.5673

HELIX: 0.0246

FCONS_SCORE: 1.2794

RIG_SCORE: 0.6852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1213R	TCGA-50-7109	LUAD	TCGA	PAATPLPE	DEG_SCF_FBW7_2	0.7512
p.D1205Y	TCGA-A5-A0G2	UCEC	TCGA	PAATPLPE	DEG_SCF_FBW7_2	0.2222
p.K1201T	TCGA-AD-6889	COAD	TCGA	PAATPLPE	DEG_SCF_FBW7_2	0.2222
p.A1211S	TCGA-AG-3592	READ	TCGA	PAATPLPE	DEG_SCF_FBW7_2	0.6477
p.A1211T	TCGA-AP-A059	UCEC	TCGA	PAATPLPE	DEG_SCF_FBW7_2	0.6028
p.T1212I	TCGA-AX-A06F	UCEC	TCGA	PAATPLPE	DEG_SCF_FBW7_2	0.7078
p.G1225V	TCGA-B5-A1MW	UCEC	TCGA	PAATPLPE	DEG_SCF_FBW7_2	0.0833
p.D1222H	TCGA-CR-6472	HNSC	TCGA	PAATPLPE	DEG_SCF_FBW7_2	0.1667
p.I1223M	TCGA-D1-A103	UCEC	TCGA	PAATPLPE	DEG_SCF_FBW7_2	0.1389
p.E1216Q	TCGA-MV-A51V	BLCA	TCGA	PAATPLPE	DEG_SCF_FBW7_2	0.6744
p.E1210K	DO234191	ESAD	ICGC	PAATPLPE	DEG_SCF_FBW7_2	0.7022
p.K1218R	DO229505	LAML	ICGC	PAATPLPE	DEG_SCF_FBW7_2	0.2778
p.V1202F	DO231016	LUSC	ICGC	PAATPLPE	DEG_SCF_FBW7_2	0.1389
p.R1221M	DO232761	PBCA	ICGC	PAATPLPE	DEG_SCF_FBW7_2	0.1944
p.G1213C	DO220315	SARC	ICGC	PAATPLPE	DEG_SCF_FBW7_2	0.76
p.S1214F	DO37819	SKCM	ICGC	PAATPLPE	DEG_SCF_FBW7_2	0.7982
p.A1206T	SIDM01307	Colorectal Carcinoma	GDSC	PAATPLPE	DEG_SCF_FBW7_2	0.25
p.K1201E	ACH-000961	Endometrial/Uterine Cancer	CCLE	PAATPLPE	DEG_SCF_FBW7_2	0.2222
p.K1218T	HCC2998	large_intestine	COSMIC	PAATPLPE	DEG_SCF_FBW7_2	0.2778
p.F1221V	HT-115	large_intestine	COSMIC	PAATPLPE	DEG_SCF_FBW7_2	0.1944
p.E1214G	HEC-1	endometrium	COSMIC	PAATPLPE	DEG_SCF_FBW7_2	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7P9	Pleckstrin homology domain-containing family G member 2	DEG_SCF_FBW7_2	1209:1216	PAATPLPE	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons