DegronMD

Uniprot ID: Q9H7P9

Source protein: Pleckstrin homology domain-containing family G member 2

Source gene: PLEKHG2

Class: DEG_SCF_FBW7_1

Location: 1256:1261

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 90.0667

COIL: 0.9753

CONS_SCORE: 0.4004

DSS_SCORE: 0.7123

HELIX: 0.01

FCONS_SCORE: 1.1251

RIG_SCORE: 0.5487

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1262L	TCGA-A5-A0G1	UCEC	TCGA	LTPPHS	DEG_SCF_FBW7_1	0.3056
p.P1264S	TCGA-D6-6516	HNSC	TCGA	LTPPHS	DEG_SCF_FBW7_1	0.25
p.P1264L	TCGA-D6-6516	HNSC	TCGA	LTPPHS	DEG_SCF_FBW7_1	0.25
p.S1265F	TCGA-EE-A2MJ	SKCM	TCGA	LTPPHS	DEG_SCF_FBW7_1	0.6667
p.T1257A	TCGA-EO-A22U	UCEC	TCGA	LTPPHS	DEG_SCF_FBW7_1	0.825
p.A1271P	DO233947	GACA	ICGC	LTPPHS	DEG_SCF_FBW7_1	0.0556
p.G1266R	DO52166	LIHC	ICGC	LTPPHS	DEG_SCF_FBW7_1	0.6389
p.L1252M	DO42568	UCEC	ICGC	LTPPHS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7P9	Pleckstrin homology domain-containing family G member 2	DEG_SCF_FBW7_1	1256:1261	LTPPHS	FBXW7	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons