DegronMD

Uniprot ID: Q9H7P9

Source protein: Pleckstrin homology domain-containing family G member 2

Source gene: PLEKHG2

Class: DEG_SCF_FBW7_1

Location: 677:684

E3 ligase: FBXW7

DEGRON score: 0.9655

ASA_SCORE: 85.4375

COIL: 0.9254

CONS_SCORE: 0.3332

DSS_SCORE: 0.4667

HELIX: 0.0514

FCONS_SCORE: 1.1502

RIG_SCORE: 0.6376

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S690F	TCGA-AB-2868	LAML	TCGA	VPNTPSLS	DEG_SCF_FBW7_1	0.1667
p.L689I	TCGA-AP-A1DK	UCEC	TCGA	VPNTPSLS	DEG_SCF_FBW7_1	0.1944
p.P675H	TCGA-ZB-A966	THYM	TCGA	VPNTPSLS	DEG_SCF_FBW7_1	0.2778
p.P677A	DO229342	BTCA	ICGC	VPNTPSLS	DEG_SCF_FBW7_1	0.7503
p.A676T	DO31150	OV	ICGC	VPNTPSLS	DEG_SCF_FBW7_1	0.3056
p.P689L	DO219487	SKCM	ICGC	VPNTPSLS	DEG_SCF_FBW7_1	0.1944
p.P669H	DO42280	UCEC	ICGC	VPNTPSLS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7P9	Pleckstrin homology domain-containing family G member 2	DEG_SCF_FBW7_1	677:684	VPNTPSLS	FBXW7	0.9655	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons