DegronMD

Uniprot ID: Q9H7P9

Source protein: Pleckstrin homology domain-containing family G member 2

Source gene: PLEKHG2

Class: DEG_SCF_FBW7_1

Location: 66:73

E3 ligase: FBXW7

DEGRON score: 0.9952

ASA_SCORE: 71.025

COIL: 0.8631

CONS_SCORE: 0.3827

DSS_SCORE: 0.7381

HELIX: 0.0914

FCONS_SCORE: 1.0955

RIG_SCORE: 0.5685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G62R	TCGA-AO-A1KS	BRCA	TCGA	PGPTPACS	DEG_SCF_FBW7_1	0.2222
p.G62R	DO1547	BRCA	ICGC	PGPTPACS	DEG_SCF_FBW7_1	0.2222
p.A65D	DO50733	ORCA	ICGC	PGPTPACS	DEG_SCF_FBW7_1	0.3056
p.A74T	SIDM00383	Gastric Carcinoma	GDSC	PGPTPACS	DEG_SCF_FBW7_1	0.3056
p.P66T	SIDM00980	Gastric Carcinoma	GDSC	PGPTPACS	DEG_SCF_FBW7_1	0.7031
p.P66T	ACH-000948	Gastric Cancer	CCLE	PGPTPACS	DEG_SCF_FBW7_1	0.7031
p.V83L	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	PGPTPACS	DEG_SCF_FBW7_1	0.0556
p.I65T	SKN	soft_tissue	COSMIC	PGPTPACS	DEG_SCF_FBW7_1	0.3056
p.V66M	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	PGPTPACS	DEG_SCF_FBW7_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7P9	Pleckstrin homology domain-containing family G member 2	DEG_SCF_FBW7_1	66:73	PGPTPACS	FBXW7	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons