DegronMD

Uniprot ID: Q9H7P9

Source protein: Pleckstrin homology domain-containing family G member 2

Source gene: PLEKHG2

Class: DEG_SCF_FBW7_1

Location: 1226:1233

E3 ligase: FBXW7

DEGRON score: 0.981

ASA_SCORE: 69.65

COIL: 0.7726

CONS_SCORE: 0.3171

DSS_SCORE: 0.535

HELIX: 0.1236

FCONS_SCORE: 1.1423

RIG_SCORE: 0.7038

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1225V	TCGA-B5-A1MW	UCEC	TCGA	LSPTPVQT	DEG_SCF_FBW7_1	0.3056
p.D1222H	TCGA-CR-6472	HNSC	TCGA	LSPTPVQT	DEG_SCF_FBW7_1	0.2222
p.I1223M	TCGA-D1-A103	UCEC	TCGA	LSPTPVQT	DEG_SCF_FBW7_1	0.25
p.S1243F	TCGA-EE-A2MR	SKCM	TCGA	LSPTPVQT	DEG_SCF_FBW7_1	0.0556
p.G1242C	TCGA-X6-A7WC	SARC	TCGA	LSPTPVQT	DEG_SCF_FBW7_1	0.0833
p.L1231V	DO234233	ESAD	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	0.6765
p.Q1229E	DO44450	HNSC	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	0.6744
p.Q1229E	DO26442	LUSC	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	0.6744
p.P1235L	DO15623	HNSC	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	0.2778
p.P1235S	DO15623	HNSC	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	0.2778
p.K1218R	DO229505	LAML	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	0.1111
p.R1221M	DO232761	PBCA	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	0.1944
p.S1236F	DO38099	SKCM	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	0.25
p.T1228A	DO43755	UCEC	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	0.7139
p.P1233L	DO42472	UCEC	ICGC	LSPTPVQT	DEG_SCF_FBW7_1	0.7582
p.P1228S	MEL-JUSO	skin	COSMIC	LSPTPVQT	DEG_SCF_FBW7_1	0.5641
p.K1218T	HCC2998	large_intestine	COSMIC	LSPTPVQT	DEG_SCF_FBW7_1	0.1111
p.F1221V	HT-115	large_intestine	COSMIC	LSPTPVQT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7P9	Pleckstrin homology domain-containing family G member 2	DEG_SCF_FBW7_1	1226:1233	LSPTPVQT	FBXW7	0.981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons