DegronMD

Uniprot ID: Q9H7P9

Source protein: Pleckstrin homology domain-containing family G member 2

Source gene: PLEKHG2

Class: DEG_SCF_FBW7_2

Location: 1194:1199

E3 ligase: FBXW7

DEGRON score: 0.9938

ASA_SCORE: 79.4833

COIL: 0.741

CONS_SCORE: 0.3349

DSS_SCORE: 0.5674

HELIX: 0.2138

FCONS_SCORE: 1.1348

RIG_SCORE: 0.7121

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1185I	TCGA-55-8506	LUAD	TCGA	LTPSLE	DEG_SCF_FBW7_2	0.0833
p.D1205Y	TCGA-A5-A0G2	UCEC	TCGA	LTPSLE	DEG_SCF_FBW7_2	0.1667
p.S1197L	TCGA-A5-A0GP	UCEC	TCGA	LTPSLE	DEG_SCF_FBW7_2	0.6556
p.S1197L	TCGA-DF-A2KU	UCEC	TCGA	LTPSLE	DEG_SCF_FBW7_2	0.6556
p.S1197L	TCGA-FW-A3R5	SKCM	TCGA	LTPSLE	DEG_SCF_FBW7_2	0.6556
p.S1197L	SIDM00889	Cervical Carcinoma	GDSC	LTPSLE	DEG_SCF_FBW7_2	0.6556
p.S1197L	ACH-001333	Cervical Cancer	CCLE	LTPSLE	DEG_SCF_FBW7_2	0.6556
p.S1197L	C-33-A	cervix	COSMIC	LTPSLE	DEG_SCF_FBW7_2	0.6556
p.P1184S	TCGA-AL-3468	KIRP	TCGA	LTPSLE	DEG_SCF_FBW7_2	0.0556
p.D1188N	TCGA-EE-A180	SKCM	TCGA	LTPSLE	DEG_SCF_FBW7_2	0.1667
p.E1187Q	DO474	BLCA	ICGC	LTPSLE	DEG_SCF_FBW7_2	0.1389
p.G1189R	DO225353	BRCA	ICGC	LTPSLE	DEG_SCF_FBW7_2	0.1944
p.L1192V	DO233667	GACA	ICGC	LTPSLE	DEG_SCF_FBW7_2	0.2778
p.D1193H	DO15870	HNSC	ICGC	LTPSLE	DEG_SCF_FBW7_2	0.3056
p.P1184R	DO24487	LUAD	ICGC	LTPSLE	DEG_SCF_FBW7_2	0.0556
p.V1202F	DO231016	LUSC	ICGC	LTPSLE	DEG_SCF_FBW7_2	0.25
p.I1194M	DO42312	UCEC	ICGC	LTPSLE	DEG_SCF_FBW7_2	0.7618
p.G1196V	DO42913	UCEC	ICGC	LTPSLE	DEG_SCF_FBW7_2	0.7532
p.A1206T	SIDM01307	Colorectal Carcinoma	GDSC	LTPSLE	DEG_SCF_FBW7_2	0.1389
p.L1185S	ONS-76	central_nervous_system	COSMIC	LTPSLE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7P9	Pleckstrin homology domain-containing family G member 2	DEG_SCF_FBW7_2	1194:1199	LTPSLE	FBXW7	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons