DegronMD

Uniprot ID: Q9H7P9

Source protein: Pleckstrin homology domain-containing family G member 2

Source gene: PLEKHG2

Class: DEG_SCF_FBW7_2

Location: 983:990

E3 ligase: FBXW7

DEGRON score: 0.995

ASA_SCORE: 82.9625

COIL: 0.8276

CONS_SCORE: 0.3029

DSS_SCORE: 0.6433

HELIX: 0.142

FCONS_SCORE: 1.1506

RIG_SCORE: 0.6625

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G976D	TCGA-AX-A3FX	UCEC	TCGA	PATTPLPE	DEG_SCF_FBW7_2	0.1389
p.D974N	TCGA-DD-A4NO	LIHC	TCGA	PATTPLPE	DEG_SCF_FBW7_2	0.0833
p.E996D	DO222884	COCA	ICGC	PATTPLPE	DEG_SCF_FBW7_2	0.1667
p.E996K	DO52672	MALY	ICGC	PATTPLPE	DEG_SCF_FBW7_2	0.1667
p.V987I	DO51298	SKCM	ICGC	PATTPLPE	DEG_SCF_FBW7_2	0.7076
p.E996A	DO38288	STAD	ICGC	PATTPLPE	DEG_SCF_FBW7_2	0.1667
p.A974T	DO43306	UCEC	ICGC	PATTPLPE	DEG_SCF_FBW7_2	0.0833
p.H981R	DO41127	UCEC	ICGC	PATTPLPE	DEG_SCF_FBW7_2	0.2778
p.H991R	SIDM00965	Small Cell Lung Carcinoma	GDSC	PATTPLPE	DEG_SCF_FBW7_2	0.3056
p.H991R	ACH-000800	Lung Cancer	CCLE	PATTPLPE	DEG_SCF_FBW7_2	0.3056
p.H991R	NCI-H446	lung	COSMIC	PATTPLPE	DEG_SCF_FBW7_2	0.3056
p.E990K	ACH-000975	Lung Cancer	CCLE	PATTPLPE	DEG_SCF_FBW7_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7P9	Pleckstrin homology domain-containing family G member 2	DEG_SCF_FBW7_2	983:990	PATTPLPE	FBXW7	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons