DegronMD

Uniprot ID: P48444

Source protein: Coatomer subunit delta

Source gene: ARCN1

Class: LIG_APCC_ABBA_1

Location: 313:318

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7648

ASA_SCORE: 36.7333

COIL: 0.1215

CONS_SCORE: 0.3867

DSS_SCORE: 0.3864

HELIX: 0.0073

FCONS_SCORE: 0.9913

RIG_SCORE: 0.7894

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R314C	TCGA-A5-A0GP	UCEC	TCGA	IRLHVE	LIG_APCC_ABBA_1	0.719
p.R314C	DO41109	UCEC	ICGC	IRLHVE	LIG_APCC_ABBA_1	0.719
p.D307Y	TCGA-EE-A20F	SKCM	TCGA	IRLHVE	LIG_APCC_ABBA_1	0.1667
p.D307Y	DO37961	SKCM	ICGC	IRLHVE	LIG_APCC_ABBA_1	0.1667
p.G311C	DO228985	LICA	ICGC	IRLHVE	LIG_APCC_ABBA_1	0.2778
p.T324A	ACH-000990	Endometrial/Uterine Cancer	CCLE	IRLHVE	LIG_APCC_ABBA_1	0.1667
p.I305T	SU-DHL-5	haematopoietic_and_lymphoid_tissue	COSMIC	IRLHVE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48444	Coatomer subunit delta	LIG_APCC_ABBA_1	313:318	IRLHVE	APC,CDC20,FZR1	0.7648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons