DegronMD - P48444(ARCN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R314C	TCGA-A5-A0GP	UCEC	TCGA	IRLHVE	LIG_APCC_ABBA_1	313:318	Mutation altering degron motif	0.719
p.R314C	TCGA-A5-A0GP	UCEC	TCGA	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.719
p.R314C	DO41109	UCEC	ICGC	IRLHVE	LIG_APCC_ABBA_1	313:318	Mutation altering degron motif	0.719
p.R314C	DO41109	UCEC	ICGC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.719
p.D307Y	TCGA-EE-A20F	SKCM	TCGA	IRLHVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.1667
p.D307Y	TCGA-EE-A20F	SKCM	TCGA	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation rewiring degron network	0.1944
p.D307Y	DO37961	SKCM	ICGC	IRLHVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.1667
p.D307Y	DO37961	SKCM	ICGC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation rewiring degron network	0.1944
p.G311C	DO228985	LICA	ICGC	IRLHVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.2778
p.G311C	DO228985	LICA	ICGC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation rewiring degron network	0.3056
p.R312Q	SIDM00993	Plasma Cell Myeloma	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.7329
p.R312Q	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.7329
p.R312Q	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.7329
p.R312Q	SIDM00502	B-Lymphoblastic Leukemia	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.7329
p.R312Q	SIDM00997	Thyroid Gland Carcinoma	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.7329
p.R312Q	SIDM01582	Gastric Carcinoma	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.7329
p.R312Q	SIDM00959	Acute Myeloid Leukemia	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.7329
p.R312Q	SIDM01413	Oral Cavity Carcinoma	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.7329
p.T324A	ACH-000990	Endometrial/Uterine Cancer	CCLE	IRLHVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.1667
p.T324A	ACH-000990	Endometrial/Uterine Cancer	CCLE	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation rewiring degron network	0.1667
p.I305T	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	IRLHVE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.1111
p.I305T	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation rewiring degron network	0.1389

Kaplan plot for ARCN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARCN1

UniProt ID: P48444

Entrez ID: 372

Protein name: Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARCN1 in