DegronMD

Uniprot ID: P48444

Source protein: Coatomer subunit delta

Source gene: ARCN1

Class: LIG_APCC_ABBAyCdc20_2

Location: 312:318

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7451

ASA_SCORE: 44.2143

COIL: 0.1324

CONS_SCORE: 0.3788

DSS_SCORE: 0.3767

HELIX: 0.0084

FCONS_SCORE: 0.9532

RIG_SCORE: 0.783

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R314C	TCGA-A5-A0GP	UCEC	TCGA	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.719
p.R314C	DO41109	UCEC	ICGC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.719
p.D307Y	TCGA-EE-A20F	SKCM	TCGA	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D307Y	DO37961	SKCM	ICGC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G311C	DO228985	LICA	ICGC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R312Q	SIDM00993	Plasma Cell Myeloma	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R312Q	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R312Q	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R312Q	SIDM00502	B-Lymphoblastic Leukemia	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R312Q	SIDM00997	Thyroid Gland Carcinoma	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R312Q	SIDM01582	Gastric Carcinoma	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R312Q	SIDM00959	Acute Myeloid Leukemia	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R312Q	SIDM01413	Oral Cavity Carcinoma	GDSC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.7329
p.T324A	ACH-000990	Endometrial/Uterine Cancer	CCLE	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.1667
p.I305T	SU-DHL-5	haematopoietic_and_lymphoid_tissue	COSMIC	RIRLHVE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48444	Coatomer subunit delta	LIG_APCC_ABBAyCdc20_2	312:318	RIRLHVE	APC,CDC20,FZR1	0.7451	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons