DegronMD

Uniprot ID: Q86VR7

Source protein: V-set and immunoglobulin domain-containing protein 10-like

Source gene: VSIG10L

Class: DEG_APCC_DBOX_1

Location: 207:215

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6956

ASA_SCORE: 50.7444

COIL: 0.2984

CONS_SCORE: 0.7908

DSS_SCORE: 0.2658

HELIX: 0.0013

FCONS_SCORE: 0.941

RIG_SCORE: 0.8215

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L211P	DO220883	MELA	ICGC	IRLPLVPIP	DEG_APCC_DBOX_1	0.7582
p.A200D	DO232016	ORCA	ICGC	IRLPLVPIP	DEG_APCC_DBOX_1	0.1389
p.L199F	ACH-001369	Ovarian Cancer	CCLE	IRLPLVPIP	DEG_APCC_DBOX_1	0.1111
p.R208W	ACH-001688	Kidney Cancer	CCLE	IRLPLVPIP	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VR7	V-set and immunoglobulin domain-containing protein 10-like	DEG_APCC_DBOX_1	207:215	IRLPLVPIP	APC,CDC20,FZR1	0.6956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons