DegronMD - Q86VR7(VSIG10L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P106L	TCGA-2W-A8YY	CESC	TCGA	VSPFSE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.3056
p.P106L	DO223732	CESC	ICGC	VSPFSE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.3056
p.P106L	DO229058	LICA	ICGC	VSPFSE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.3056
p.P120S	TCGA-FI-A2D5	UCEC	TCGA	VSPFSE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1111
p.P120S	DO41331	UCEC	ICGC	VSPFSE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1111
p.S111C	DO52551	BRCA	ICGC	VSPFSE	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.643
p.R483C	DO234342	ESAD	ICGC	RRRSLLNLT	DEG_APCC_DBOX_1	481:489	Mutation altering degron motif	0.719
p.P494T	DO228986	LICA	ICGC	RRRSLLNLT	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.1944
p.P120T	DO229018	LICA	ICGC	VSPFSE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1111
p.L211P	DO220883	MELA	ICGC	IRLPLVPIP	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.7582
p.A200D	DO232016	ORCA	ICGC	IRLPLVPIP	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1389
p.P114R	DO33070	PACA	ICGC	VSPFSE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778
p.L199F	ACH-001369	Ovarian Cancer	CCLE	IRLPLVPIP	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1111
p.P109R	ACH-001402	Cervical Cancer	CCLE	VSPFSE	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.7512
p.S111Y	ACH-001416	Bladder Cancer	CCLE	VSPFSE	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.6009
p.R208W	ACH-001688	Kidney Cancer	CCLE	IRLPLVPIP	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.8634

Kaplan plot for VSIG10L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VSIG10L

UniProt ID: Q86VR7

Entrez ID: 147645

Protein name: V-set and immunoglobulin domain-containing protein 10-like (VSIG10-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VSIG10L in