DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RRRSLLNLT
Uniprot ID:
Q86VR7
Source protein:
V-set and immunoglobulin domain-containing protein 10-like
Source gene:
VSIG10L
Class:
DEG_APCC_DBOX_1
Location:
481:489
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6407
ASA_SCORE:
69.4111
COIL:
0.0336
CONS_SCORE:
0.8825
DSS_SCORE:
0.4876
HELIX:
0.0014
FCONS_SCORE:
0.9711
RIG_SCORE:
0.78
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R483C
DO234342
ESAD
ICGC
RRRSLLNLT
DEG_APCC_DBOX_1
0.719
p.P494T
DO228986
LICA
ICGC
RRRSLLNLT
DEG_APCC_DBOX_1
0.1944
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Drug responses associated with VSIG10L mutations
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Cancer
Mutation (In Degron?)
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Drug
IC50
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All proteins holding degron of RRRSLLNLT
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86VR7
V-set and immunoglobulin domain-containing protein 10-like
DEG_APCC_DBOX_1
481:489
RRRSLLNLT
APC,CDC20,FZR1
0.6407
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