DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RRRSLLNLT
Uniprot ID:
Q86VR7
Source protein:
V-set and immunoglobulin domain-containing protein 10-like
Source gene:
VSIG10L
Class:
DEG_APCC_DBOX_1
Location:
481:489
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6407
ASA_SCORE:
69.4111
COIL:
0.0336
CONS_SCORE:
0.8825
DSS_SCORE:
0.4876
HELIX:
0.0014
FCONS_SCORE:
0.9711
RIG_SCORE:
0.78
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R483C
DO234342
ESAD
ICGC
RRRSLLNLT
DEG_APCC_DBOX_1
0.719
p.P494T
DO228986
LICA
ICGC
RRRSLLNLT
DEG_APCC_DBOX_1
0.1944
Drug responses associated with VSIG10L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRRSLLNLT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86VR7
V-set and immunoglobulin domain-containing protein 10-like
DEG_APCC_DBOX_1
481:489
RRRSLLNLT
APC,CDC20,FZR1
0.6407
More...