DegronMD

Uniprot ID: Q86VR7

Source protein: V-set and immunoglobulin domain-containing protein 10-like

Source gene: VSIG10L

Class: LIG_APCC_ABBA_1

Location: 107:112

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8904

ASA_SCORE: 69.4167

COIL: 0.5862

CONS_SCORE: 0.5387

DSS_SCORE: 0.6251

HELIX: 0.012

FCONS_SCORE: 0.8696

RIG_SCORE: 0.6242

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P106L	TCGA-2W-A8YY	CESC	TCGA	VSPFSE	LIG_APCC_ABBA_1	0.3056
p.P106L	DO223732	CESC	ICGC	VSPFSE	LIG_APCC_ABBA_1	0.3056
p.P106L	DO229058	LICA	ICGC	VSPFSE	LIG_APCC_ABBA_1	0.3056
p.P120S	TCGA-FI-A2D5	UCEC	TCGA	VSPFSE	LIG_APCC_ABBA_1	0.1111
p.P120S	DO41331	UCEC	ICGC	VSPFSE	LIG_APCC_ABBA_1	0.1111
p.S111C	DO52551	BRCA	ICGC	VSPFSE	LIG_APCC_ABBA_1	0.643
p.P120T	DO229018	LICA	ICGC	VSPFSE	LIG_APCC_ABBA_1	0.1111
p.P114R	DO33070	PACA	ICGC	VSPFSE	LIG_APCC_ABBA_1	0.2778
p.P109R	ACH-001402	Cervical Cancer	CCLE	VSPFSE	LIG_APCC_ABBA_1	0.7512
p.S111Y	ACH-001416	Bladder Cancer	CCLE	VSPFSE	LIG_APCC_ABBA_1	0.6009

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VR7	V-set and immunoglobulin domain-containing protein 10-like	LIG_APCC_ABBA_1	107:112	VSPFSE	APC,CDC20,FZR1	0.8904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons