DegronMD

Uniprot ID: Q14152

Source protein: Eukaryotic translation initiation factor 3 subunit A

Source gene: EIF3A

Class: DEG_APCC_DBOX_1

Location: 519:527

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8116

ASA_SCORE: 59.0444

COIL: 0.0389

CONS_SCORE: 0.4633

DSS_SCORE: 0.3745

HELIX: 0.9586

FCONS_SCORE: 1.3152

RIG_SCORE: 0.7497

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P515L	TCGA-2L-AAQM	PAAD	TCGA	IRNQLTAMS	DEG_APCC_DBOX_1	0.2222
p.R520I	TCGA-AA-A00N	COAD	TCGA	IRNQLTAMS	DEG_APCC_DBOX_1	0.8102
p.A533T	TCGA-DU-6392	LGG	TCGA	IRNQLTAMS	DEG_APCC_DBOX_1	0.1667
p.A525S	TCGA-VQ-A8P2	STAD	TCGA	IRNQLTAMS	DEG_APCC_DBOX_1	0.6477
p.R537H	DO9002	COAD	ICGC	IRNQLTAMS	DEG_APCC_DBOX_1	0.0556
p.R533W	DO234375	ESAD	ICGC	IRNQLTAMS	DEG_APCC_DBOX_1	0.1667
p.A522E	DO229027	LICA	ICGC	IRNQLTAMS	DEG_APCC_DBOX_1	0.7701
p.Q532K	DO229036	LICA	ICGC	IRNQLTAMS	DEG_APCC_DBOX_1	0.3056
p.R528Q	DO41903	UCEC	ICGC	IRNQLTAMS	DEG_APCC_DBOX_1	0.75
p.Q515R	DO42713	UCEC	ICGC	IRNQLTAMS	DEG_APCC_DBOX_1	0.2222
p.V529I	SIDM01016	T-Lymphoblastic Leukemia	GDSC	IRNQLTAMS	DEG_APCC_DBOX_1	0.2778
p.V529I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	IRNQLTAMS	DEG_APCC_DBOX_1	0.2778
p.V529I	ACH-000995	Leukemia	CCLE	IRNQLTAMS	DEG_APCC_DBOX_1	0.2778
p.V529I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	IRNQLTAMS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14152	Eukaryotic translation initiation factor 3 subunit A	DEG_APCC_DBOX_1	519:527	IRNQLTAMS	APC,CDC20,FZR1	0.8116	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons