DegronMD - Q14152(EIF3A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P515L	TCGA-2L-AAQM	PAAD	TCGA	IRNQLTAMS	DEG_APCC_DBOX_1	519:527	Mutation rewiring degron network	0.2222
p.R520I	TCGA-AA-A00N	COAD	TCGA	IRNQLTAMS	DEG_APCC_DBOX_1	519:527	Mutation altering degron motif	0.8102
p.T336M	TCGA-AD-5900	COAD	TCGA	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1111
p.T336M	TCGA-FP-A4BE	STAD	TCGA	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1111
p.R335H	TCGA-AX-A05Z	UCEC	TCGA	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1389
p.R335H	TCGA-CM-4743	COAD	TCGA	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1389
p.S319P	TCGA-BR-8680	STAD	TCGA	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.3056
p.A533T	TCGA-DU-6392	LGG	TCGA	IRNQLTAMS	DEG_APCC_DBOX_1	519:527	Mutation rewiring degron network	0.1667
p.A525S	TCGA-VQ-A8P2	STAD	TCGA	IRNQLTAMS	DEG_APCC_DBOX_1	519:527	Mutation altering degron motif	0.6477
p.R537H	DO9002	COAD	ICGC	IRNQLTAMS	DEG_APCC_DBOX_1	519:527	Mutation rewiring degron network	0.0556
p.G312V	DO8312	COAD	ICGC	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1111
p.R533W	DO234375	ESAD	ICGC	IRNQLTAMS	DEG_APCC_DBOX_1	519:527	Mutation rewiring degron network	0.1667
p.R320H	DO233624	GACA	ICGC	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation altering degron motif	0.8244
p.A522E	DO229027	LICA	ICGC	IRNQLTAMS	DEG_APCC_DBOX_1	519:527	Mutation altering degron motif	0.7701
p.Q532K	DO229036	LICA	ICGC	IRNQLTAMS	DEG_APCC_DBOX_1	519:527	Mutation substituting flanking lysine	0.3056
p.P330L	DO45547	LUSC	ICGC	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.2778
p.R320C	DO37406	SKCM	ICGC	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation altering degron motif	0.8301
p.M310I	DO47636	SKCM	ICGC	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.0556
p.P330T	DO47569	SKCM	ICGC	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.2778
p.R528Q	DO41903	UCEC	ICGC	IRNQLTAMS	DEG_APCC_DBOX_1	519:527	Mutation blocking phosphorylation signal	0.75
p.Q515R	DO42713	UCEC	ICGC	IRNQLTAMS	DEG_APCC_DBOX_1	519:527	Mutation rewiring degron network	0.2222
p.V529I	SIDM01016	T-Lymphoblastic Leukemia	GDSC	IRNQLTAMS	DEG_APCC_DBOX_1	519:527	Mutation rewiring degron network	0.2778
p.V529I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	IRNQLTAMS	DEG_APCC_DBOX_1	519:527	Mutation rewiring degron network	0.2778
p.V529I	ACH-000995	Leukemia	CCLE	IRNQLTAMS	DEG_APCC_DBOX_1	519:527	Mutation rewiring degron network	0.2778
p.V529I	Jurkat	haematopoietic and lymphoid tissue	COSMIC	IRNQLTAMS	DEG_APCC_DBOX_1	519:527	Mutation rewiring degron network	0.2778
p.P330S	SIDM01146	Gastric Carcinoma	GDSC	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.2778
p.P330S	ACH-000932	Gastric Cancer	CCLE	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.2778
p.P330S	NCI-SNU-1	stomach	COSMIC	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.2778
p.R335C	SIDM00901	Endometrial Carcinoma	GDSC	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1389
p.R335C	ACH-000940	Endometrial/Uterine Cancer	CCLE	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1389
p.R335C	AN3-CA	endometrium	COSMIC	TRVLLATLS	DEG_APCC_DBOX_1	320:328	Mutation rewiring degron network	0.1389

Kaplan plot for EIF3A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EIF3A

UniProt ID: Q14152

Entrez ID: 8661

Protein name: Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EIF3A in