DegronMD

Uniprot ID: Q14152

Source protein: Eukaryotic translation initiation factor 3 subunit A

Source gene: EIF3A

Class: DEG_APCC_DBOX_1

Location: 320:328

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8129

ASA_SCORE: 16.0444

COIL: 0.0982

CONS_SCORE: 0.6655

DSS_SCORE: 0.2783

HELIX: 0.8941

FCONS_SCORE: 1.6068

RIG_SCORE: 0.8409

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T336M	TCGA-AD-5900	COAD	TCGA	TRVLLATLS	DEG_APCC_DBOX_1	0.1111
p.T336M	TCGA-FP-A4BE	STAD	TCGA	TRVLLATLS	DEG_APCC_DBOX_1	0.1111
p.R335H	TCGA-AX-A05Z	UCEC	TCGA	TRVLLATLS	DEG_APCC_DBOX_1	0.1389
p.R335H	TCGA-CM-4743	COAD	TCGA	TRVLLATLS	DEG_APCC_DBOX_1	0.1389
p.S319P	TCGA-BR-8680	STAD	TCGA	TRVLLATLS	DEG_APCC_DBOX_1	0.3056
p.G312V	DO8312	COAD	ICGC	TRVLLATLS	DEG_APCC_DBOX_1	0.1111
p.R320H	DO233624	GACA	ICGC	TRVLLATLS	DEG_APCC_DBOX_1	0.8244
p.P330L	DO45547	LUSC	ICGC	TRVLLATLS	DEG_APCC_DBOX_1	0.2778
p.R320C	DO37406	SKCM	ICGC	TRVLLATLS	DEG_APCC_DBOX_1	0.8301
p.M310I	DO47636	SKCM	ICGC	TRVLLATLS	DEG_APCC_DBOX_1	0.0556
p.P330T	DO47569	SKCM	ICGC	TRVLLATLS	DEG_APCC_DBOX_1	0.2778
p.P330S	SIDM01146	Gastric Carcinoma	GDSC	TRVLLATLS	DEG_APCC_DBOX_1	0.2778
p.P330S	ACH-000932	Gastric Cancer	CCLE	TRVLLATLS	DEG_APCC_DBOX_1	0.2778
p.P330S	NCI-SNU-1	stomach	COSMIC	TRVLLATLS	DEG_APCC_DBOX_1	0.2778
p.R335C	SIDM00901	Endometrial Carcinoma	GDSC	TRVLLATLS	DEG_APCC_DBOX_1	0.1389
p.R335C	ACH-000940	Endometrial/Uterine Cancer	CCLE	TRVLLATLS	DEG_APCC_DBOX_1	0.1389
p.R335C	AN3-CA	endometrium	COSMIC	TRVLLATLS	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14152	Eukaryotic translation initiation factor 3 subunit A	DEG_APCC_DBOX_1	320:328	TRVLLATLS	APC,CDC20,FZR1	0.8129	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons