DegronMD

Uniprot ID: P30305

Source protein: M-phase inducer phosphatase 2

Source gene: CDC25B

Class: DEG_APCC_DBOX_1

Location: 329:337

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9979

ASA_SCORE: 108.4667

COIL: 0.7786

CONS_SCORE: 0.3257

DSS_SCORE: 0.525

HELIX: 0.196

FCONS_SCORE: 1.0253

RIG_SCORE: 0.7816

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P331A	TCGA-BA-6868	HNSC	TCGA	IRPILKRLE	DEG_APCC_DBOX_1	0.6392
p.R338Q	TCGA-BR-7707	STAD	TCGA	IRPILKRLE	DEG_APCC_DBOX_1	0.3056
p.R338Q	DO38487	STAD	ICGC	IRPILKRLE	DEG_APCC_DBOX_1	0.3056
p.P339L	TCGA-D5-6928	COAD	TCGA	IRPILKRLE	DEG_APCC_DBOX_1	0.2778
p.P339L	DO7776	COAD	ICGC	IRPILKRLE	DEG_APCC_DBOX_1	0.2778
p.P345L	TCGA-GN-A8LK	SKCM	TCGA	IRPILKRLE	DEG_APCC_DBOX_1	0.1111
p.A335S	DO229029	LICA	ICGC	IRPILKRLE	DEG_APCC_DBOX_1	0.7588
p.A335S	DO229009	LICA	ICGC	IRPILKRLE	DEG_APCC_DBOX_1	0.7588
p.N319D	DO22950	LIHC	ICGC	IRPILKRLE	DEG_APCC_DBOX_1	0.0556
p.M324R	DO231189	LUSC	ICGC	IRPILKRLE	DEG_APCC_DBOX_1	0.1944
p.D342Y	DO26447	LUSC	ICGC	IRPILKRLE	DEG_APCC_DBOX_1	0.1944
p.R320C	DO222415	MELA	ICGC	IRPILKRLE	DEG_APCC_DBOX_1	0.0833
p.Q346K	DO47578	SKCM	ICGC	IRPILKRLE	DEG_APCC_DBOX_1	0.0833
p.D343N	SIDM00135	Breast Carcinoma	GDSC	IRPILKRLE	DEG_APCC_DBOX_1	0.1667
p.D343N	ACH-000148	Breast Cancer	CCLE	IRPILKRLE	DEG_APCC_DBOX_1	0.1667
p.D343N	Hs-578-T	breast	COSMIC	IRPILKRLE	DEG_APCC_DBOX_1	0.1667
p.P331S	SIDM01146	Gastric Carcinoma	GDSC	IRPILKRLE	DEG_APCC_DBOX_1	0.5641
p.P331S	ACH-000932	Gastric Cancer	CCLE	IRPILKRLE	DEG_APCC_DBOX_1	0.5641
p.P331S	NCI-SNU-1	stomach	COSMIC	IRPILKRLE	DEG_APCC_DBOX_1	0.5641
p.V328M	SIDM01608	Endometrial Carcinoma	GDSC	IRPILKRLE	DEG_APCC_DBOX_1	0.3056
p.R328C	PSN1	pancreas	COSMIC	IRPILKRLE	DEG_APCC_DBOX_1	0.3056
p.V329I	LS-411N	large_intestine	COSMIC	IRPILKRLE	DEG_APCC_DBOX_1	0.7076
p.D329N	Hs-578-T	breast	COSMIC	IRPILKRLE	DEG_APCC_DBOX_1	0.6932
p.V341L	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	IRPILKRLE	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30305	M-phase inducer phosphatase 2	DEG_APCC_DBOX_1	329:337	IRPILKRLE	APC,CDC20,FZR1	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons