DegronMD

Uniprot ID: O94806

Source protein: Serine/threonine-protein kinase D3

Source gene: PRKD3

Class: DEG_APCC_DBOX_1

Location: 527:535

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9958

ASA_SCORE: 74.1333

COIL: 0.5629

CONS_SCORE: 0.6404

DSS_SCORE: 0.3891

HELIX: 0.414

FCONS_SCORE: 1.1677

RIG_SCORE: 0.7992

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R528C	TCGA-AN-A046	BRCA	TCGA	IRQALMPVT	DEG_APCC_DBOX_1	0.8301
p.R528C	TCGA-B5-A0JY	UCEC	TCGA	IRQALMPVT	DEG_APCC_DBOX_1	0.8301
p.R528C	TCGA-EO-A3B0	UCEC	TCGA	IRQALMPVT	DEG_APCC_DBOX_1	0.8301
p.R528C	DO1285	BRCA	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	0.8301
p.R528C	DO219773	UCEC	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	0.8301
p.R528C	DO43041	UCEC	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	0.8301
p.R528C	ACH-000692	Head and Neck Cancer	CCLE	IRQALMPVT	DEG_APCC_DBOX_1	0.8301
p.Q529K	TCGA-BF-A1PU	SKCM	TCGA	IRQALMPVT	DEG_APCC_DBOX_1	0.5833
p.Q529K	DO50278	SKCM	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	0.5833
p.T535I	TCGA-CR-7365	HNSC	TCGA	IRQALMPVT	DEG_APCC_DBOX_1	0.7078
p.T535I	DO15991	HNSC	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	0.7078
p.G545W	TCGA-D3-A2JP	SKCM	TCGA	IRQALMPVT	DEG_APCC_DBOX_1	0.0556
p.G545W	DO47407	SKCM	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	0.0556
p.P533T	DO229018	LICA	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	0.5919
p.T535N	DO229045	LICA	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	0.7055
p.R528H	SIDM00500	Colorectal Carcinoma	GDSC	IRQALMPVT	DEG_APCC_DBOX_1	0.8244
p.R528H	ACH-000959	Colon/Colorectal Cancer	CCLE	IRQALMPVT	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94806	Serine/threonine-protein kinase D3	DEG_APCC_DBOX_1	527:535	IRQALMPVT	APC,CDC20,FZR1	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons