DegronMD - O94806(PRKD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R528C	TCGA-AN-A046	BRCA	TCGA	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.8301
p.R528C	TCGA-B5-A0JY	UCEC	TCGA	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.8301
p.R528C	TCGA-EO-A3B0	UCEC	TCGA	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.8301
p.R528C	DO1285	BRCA	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.8301
p.R528C	DO219773	UCEC	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.8301
p.R528C	DO43041	UCEC	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.8301
p.R528C	ACH-000692	Head and Neck Cancer	CCLE	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.8301
p.Q529K	TCGA-BF-A1PU	SKCM	TCGA	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.5833
p.Q529K	DO50278	SKCM	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.5833
p.T535I	TCGA-CR-7365	HNSC	TCGA	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.7078
p.T535I	TCGA-CR-7365	HNSC	TCGA	MPVTPQAS	DEG_SCF_FBW7_1	532:539	Mutation altering degron motif	0.8189
p.T535I	DO15991	HNSC	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.7078
p.T535I	DO15991	HNSC	ICGC	MPVTPQAS	DEG_SCF_FBW7_1	532:539	Mutation altering degron motif	0.8189
p.G545W	TCGA-D3-A2JP	SKCM	TCGA	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.0556
p.G545W	TCGA-D3-A2JP	SKCM	TCGA	MPVTPQAS	DEG_SCF_FBW7_1	532:539	Mutation rewiring degron network	0.1667
p.G545W	DO47407	SKCM	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.0556
p.G545W	DO47407	SKCM	ICGC	MPVTPQAS	DEG_SCF_FBW7_1	532:539	Mutation rewiring degron network	0.1667
p.G547W	DO233935	GACA	ICGC	MPVTPQAS	DEG_SCF_FBW7_1	532:539	Mutation rewiring degron network	0.1111
p.P533T	DO229018	LICA	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.5919
p.P533T	DO229018	LICA	ICGC	MPVTPQAS	DEG_SCF_FBW7_1	532:539	Mutation altering degron motif	0.5919
p.T535N	DO229045	LICA	ICGC	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.7055
p.T535N	DO229045	LICA	ICGC	MPVTPQAS	DEG_SCF_FBW7_1	532:539	Mutation altering degron motif	0.8166
p.R528H	SIDM00500	Colorectal Carcinoma	GDSC	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.8244
p.R528H	ACH-000959	Colon/Colorectal Cancer	CCLE	IRQALMPVT	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.8244

Kaplan plot for PRKD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRKD3

UniProt ID: O94806

Entrez ID: 23683

Protein name: Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRKD3 in