DegronMD

Uniprot ID: O94806

Source protein: Serine/threonine-protein kinase D3

Source gene: PRKD3

Class: DEG_SCF_FBW7_1

Location: 532:539

E3 ligase: FBXW7

DEGRON score: 0.9944

ASA_SCORE: 83.8625

COIL: 0.9154

CONS_SCORE: 0.5752

DSS_SCORE: 0.418

HELIX: 0.051

FCONS_SCORE: 1.0328

RIG_SCORE: 0.7576

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T535I	TCGA-CR-7365	HNSC	TCGA	MPVTPQAS	DEG_SCF_FBW7_1	0.8189
p.T535I	DO15991	HNSC	ICGC	MPVTPQAS	DEG_SCF_FBW7_1	0.8189
p.G545W	TCGA-D3-A2JP	SKCM	TCGA	MPVTPQAS	DEG_SCF_FBW7_1	0.1667
p.G545W	DO47407	SKCM	ICGC	MPVTPQAS	DEG_SCF_FBW7_1	0.1667
p.G547W	DO233935	GACA	ICGC	MPVTPQAS	DEG_SCF_FBW7_1	0.1111
p.P533T	DO229018	LICA	ICGC	MPVTPQAS	DEG_SCF_FBW7_1	0.5919
p.T535N	DO229045	LICA	ICGC	MPVTPQAS	DEG_SCF_FBW7_1	0.8166

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94806	Serine/threonine-protein kinase D3	DEG_SCF_FBW7_1	532:539	MPVTPQAS	FBXW7	0.9944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons