DegronMD

Uniprot ID: A2RU30

Source protein: Protein TESPA1

Source gene: TESPA1

Class: DEG_APCC_DBOX_1

Location: 409:417

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.919

ASA_SCORE: 86.8778

COIL: 0.5477

CONS_SCORE: 0.5063

DSS_SCORE: 0.5135

HELIX: 0.4253

FCONS_SCORE: 1.0023

RIG_SCORE: 0.7637

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T421M	TCGA-AG-3883	READ	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	0.2222
p.T421M	DO222503	COCA	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	0.2222
p.T421M	DO37010	READ	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	0.2222
p.T421M	SIDM01943	Colorectal Carcinoma	GDSC	IRRELCSLP	DEG_APCC_DBOX_1	0.2222
p.R410M	TCGA-D3-A2JL	SKCM	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	0.8632
p.R410M	DO47278	SKCM	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	0.8632
p.E422K	TCGA-D3-A51T	SKCM	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	0.1944
p.E422K	TCGA-WE-A8K4	SKCM	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	0.1944
p.E422K	DO229470	SKCA	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	0.1944
p.E422K	DO47389	SKCM	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	0.1944
p.E422K	DO51281	SKCM	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	0.1944
p.P406L	TCGA-DK-A3IN	BLCA	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	0.25
p.P406L	DO455	BLCA	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	0.25
p.D399N	TCGA-FW-A3R5	SKCM	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	0.0556
p.D399N	DO37406	SKCM	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	0.0556
p.T404A	TCGA-HU-A4GQ	STAD	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	0.1944
p.R411T	TCGA-P3-A6T5	HNSC	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	0.6765
p.R411T	DO49066	HNSC	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	0.6765
p.A418S	DO233277	GACA	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	0.3056
p.A418V	DO228884	LICA	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	0.3056
p.E412Q	SIDM00857	Melanoma	GDSC	IRRELCSLP	DEG_APCC_DBOX_1	0.5633
p.E412Q	ACH-000572	Skin Cancer	CCLE	IRRELCSLP	DEG_APCC_DBOX_1	0.5633
p.E412Q	G-361	skin	COSMIC	IRRELCSLP	DEG_APCC_DBOX_1	0.5633
p.E412G	ACH-000978	Endometrial/Uterine Cancer	CCLE	IRRELCSLP	DEG_APCC_DBOX_1	0.6087
p.E412G	EN	endometrium	COSMIC	IRRELCSLP	DEG_APCC_DBOX_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RU30	Protein TESPA1	DEG_APCC_DBOX_1	409:417	IRRELCSLP	APC,CDC20,FZR1	0.919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons