DegronMD - A2RU30(TESPA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P307T	TCGA-55-6979	LUAD	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.3056
p.P307T	DO24110	LUAD	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.3056
p.E318K	TCGA-90-A4ED	LUSC	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.2778
p.E318K	DO45482	LUSC	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.2778
p.D313Y	TCGA-95-A4VN	LUAD	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.6214
p.D313Y	DO51199	LUAD	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.6214
p.R299W	TCGA-AD-6895	COAD	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.0833
p.R299W	TCGA-DX-AB2E	SARC	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.0833
p.T421M	TCGA-AG-3883	READ	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.2222
p.T421M	DO222503	COCA	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.2222
p.T421M	DO37010	READ	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.2222
p.T421M	SIDM01943	Colorectal Carcinoma	GDSC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.2222
p.V315G	TCGA-BR-6453	STAD	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.7532
p.V315G	TCGA-CG-5732	STAD	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.7532
p.V315G	DO231961	LICA	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.7532
p.V315G	DO38543	STAD	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.7532
p.V315G	DO38471	STAD	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.7532
p.R309K	TCGA-CV-7252	HNSC	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.7237
p.R309K	DO14176	HNSC	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.7237
p.R410M	TCGA-D3-A2JL	SKCM	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation altering degron motif	0.8632
p.R410M	DO47278	SKCM	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation altering degron motif	0.8632
p.E422K	TCGA-D3-A51T	SKCM	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.1944
p.E422K	TCGA-WE-A8K4	SKCM	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.1944
p.E422K	DO229470	SKCA	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.1944
p.E422K	DO47389	SKCM	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.1944
p.E422K	DO51281	SKCM	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.1944
p.P406L	TCGA-DK-A3IN	BLCA	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.25
p.P406L	DO455	BLCA	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.25
p.N310D	TCGA-FR-A7U9	SKCM	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.5821
p.N310D	DO48546	SKCM	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.5821
p.D399N	TCGA-FW-A3R5	SKCM	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.0556
p.D399N	DO37406	SKCM	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.0556
p.T404A	TCGA-HU-A4GQ	STAD	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.1944
p.Q314H	TCGA-L5-A4OT	ESCA	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.647
p.Q314H	DO234462	ESAD	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.647
p.S311G	TCGA-NH-A5IV	COAD	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.6993
p.S311G	DO49095	COAD	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.6993
p.R411T	TCGA-P3-A6T5	HNSC	TCGA	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation altering degron motif	0.6765
p.R411T	DO49066	HNSC	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation altering degron motif	0.6765
p.E326D	DO222884	COCA	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.0556
p.A418S	DO233277	GACA	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.3056
p.A418V	DO228884	LICA	ICGC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation rewiring degron network	0.3056
p.V319G	DO220909	MELA	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.25
p.E412Q	SIDM00857	Melanoma	GDSC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation altering degron motif	0.5633
p.E412Q	ACH-000572	Skin Cancer	CCLE	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation altering degron motif	0.5633
p.E412Q	G-361	skin	COSMIC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation altering degron motif	0.5633
p.V319A	SIDM00680	Colorectal Carcinoma	GDSC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.25
p.V319A	ACH-000957	Colon/Colorectal Cancer	CCLE	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.25
p.V319A	LS-180	large intestine	COSMIC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.25
p.K308E	SIDM00217	Colorectal Carcinoma	GDSC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.591
p.K308E	ACH-000999	Colon/Colorectal Cancer	CCLE	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.591
p.K308E	SNU-1040	large intestine	COSMIC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.591
p.E412G	ACH-000978	Endometrial/Uterine Cancer	CCLE	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation altering degron motif	0.6087
p.E412G	EN	endometrium	COSMIC	IRRELCSLP	DEG_APCC_DBOX_1	409:417	Mutation altering degron motif	0.6087
p.R309M	ACH-002461	Skin Cancer	CCLE	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.8632
p.R299Q	ACH-002710	Sarcoma	CCLE	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.0833
p.Q324H	L-1236	haematopoietic and lymphoid tissue	COSMIC	KRNSLDQVV	DEG_APCC_DBOX_1	308:316	Mutation substituting flanking lysine	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TESPA1

UniProt ID: A2RU30

Entrez ID: 9840

Protein name: Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TESPA1 in