DegronMD

Uniprot ID: A2RU30

Source protein: Protein TESPA1

Source gene: TESPA1

Class: DEG_APCC_DBOX_1

Location: 308:316

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9794

ASA_SCORE: 92.8111

COIL: 0.4848

CONS_SCORE: 0.6848

DSS_SCORE: 0.5895

HELIX: 0.5053

FCONS_SCORE: 1.0704

RIG_SCORE: 0.7269

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P307T	TCGA-55-6979	LUAD	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	0.3056
p.P307T	DO24110	LUAD	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	0.3056
p.E318K	TCGA-90-A4ED	LUSC	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	0.2778
p.E318K	DO45482	LUSC	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	0.2778
p.D313Y	TCGA-95-A4VN	LUAD	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	0.6214
p.D313Y	DO51199	LUAD	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	0.6214
p.R299W	TCGA-AD-6895	COAD	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	0.0833
p.R299W	TCGA-DX-AB2E	SARC	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	0.0833
p.V315G	TCGA-BR-6453	STAD	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	0.7532
p.V315G	TCGA-CG-5732	STAD	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	0.7532
p.V315G	DO231961	LICA	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	0.7532
p.V315G	DO38543	STAD	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	0.7532
p.V315G	DO38471	STAD	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	0.7532
p.R309K	TCGA-CV-7252	HNSC	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	0.7237
p.R309K	DO14176	HNSC	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	0.7237
p.N310D	TCGA-FR-A7U9	SKCM	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	0.5821
p.N310D	DO48546	SKCM	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	0.5821
p.Q314H	TCGA-L5-A4OT	ESCA	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	0.647
p.Q314H	DO234462	ESAD	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	0.647
p.S311G	TCGA-NH-A5IV	COAD	TCGA	KRNSLDQVV	DEG_APCC_DBOX_1	0.6993
p.S311G	DO49095	COAD	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	0.6993
p.E326D	DO222884	COCA	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	0.0556
p.V319G	DO220909	MELA	ICGC	KRNSLDQVV	DEG_APCC_DBOX_1	0.25
p.V319A	SIDM00680	Colorectal Carcinoma	GDSC	KRNSLDQVV	DEG_APCC_DBOX_1	0.25
p.V319A	ACH-000957	Colon/Colorectal Cancer	CCLE	KRNSLDQVV	DEG_APCC_DBOX_1	0.25
p.V319A	LS-180	large_intestine	COSMIC	KRNSLDQVV	DEG_APCC_DBOX_1	0.25
p.K308E	SIDM00217	Colorectal Carcinoma	GDSC	KRNSLDQVV	DEG_APCC_DBOX_1	0.591
p.K308E	ACH-000999	Colon/Colorectal Cancer	CCLE	KRNSLDQVV	DEG_APCC_DBOX_1	0.591
p.K308E	SNU-1040	large_intestine	COSMIC	KRNSLDQVV	DEG_APCC_DBOX_1	0.591
p.R309M	ACH-002461	Skin Cancer	CCLE	KRNSLDQVV	DEG_APCC_DBOX_1	0.8632
p.R299Q	ACH-002710	Sarcoma	CCLE	KRNSLDQVV	DEG_APCC_DBOX_1	0.0833
p.Q324H	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	KRNSLDQVV	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRNSLDQVV

Degron related mutations and impact score

Drug responses associated with TESPA1 mutations

All proteins holding degron of KRNSLDQVV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RU30	Protein TESPA1	DEG_APCC_DBOX_1	308:316	KRNSLDQVV	APC,CDC20,FZR1	0.9794	More...