DegronMD

Uniprot ID: Q9P1Z9

Source protein: Coiled-coil domain-containing protein 180

Source gene: CCDC180

Class: DEG_APCC_DBOX_1

Location: 1590:1598

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9948

ASA_SCORE: 83.5778

COIL: 0.4964

CONS_SCORE: 0.5432

DSS_SCORE: 0.3111

HELIX: 0.4102

FCONS_SCORE: 1.1947

RIG_SCORE: 0.7835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1582S	TCGA-17-Z042	LUAD	TCGA	IRRKLAGLS	DEG_APCC_DBOX_1	0.1111
p.S1603N	TCGA-77-8144	LUSC	TCGA	IRRKLAGLS	DEG_APCC_DBOX_1	0.6389
p.P1582A	TCGA-95-7562	LUAD	TCGA	IRRKLAGLS	DEG_APCC_DBOX_1	0.1111
p.R1591Q	TCGA-AN-A0XU	BRCA	TCGA	IRRKLAGLS	DEG_APCC_DBOX_1	0.7329
p.R1591Q	SIDM00850	Gastric Carcinoma	GDSC	IRRKLAGLS	DEG_APCC_DBOX_1	0.7329
p.K1605N	TCGA-B7-5816	STAD	TCGA	IRRKLAGLS	DEG_APCC_DBOX_1	0.25
p.P1582L	TCGA-BS-A0V4	UCEC	TCGA	IRRKLAGLS	DEG_APCC_DBOX_1	0.1111
p.L1599M	TCGA-EJ-7125	PRAD	TCGA	IRRKLAGLS	DEG_APCC_DBOX_1	0.3056
p.D1599N	DO51612	CESC	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	0.3056
p.A1607T	DO223149	ESCA	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	0.0833
p.A1594S	DO228978	LICA	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	0.7588
p.A1594S	DO229045	LICA	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	0.7588
p.L1589Q	DO231036	LUSC	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	0.3056
p.S1583F	DO222837	MELA	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	0.25
p.A1600D	DO232224	PBCA	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	0.2778
p.S1581L	DO51407	PRAD	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	0.0833
p.S1581L	DO43907	UCEC	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	0.0833
p.S1581L	DO41235	UCEC	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	0.0833
p.S1581L	DO41211	UCEC	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	0.0833
p.S1581L	DO41488	UCEC	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	0.0833
p.V1595M	DO51346	PRAD	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	0.7208
p.A1593T	DO51301	SKCM	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	0.7139
p.P1581H	ACH-000872	Lung Cancer	CCLE	IRRKLAGLS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1Z9	Coiled-coil domain-containing protein 180	DEG_APCC_DBOX_1	1590:1598	IRRKLAGLS	APC,CDC20,FZR1	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons