DegronMD - Q9P1Z9(CCDC180)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1582S	TCGA-17-Z042	LUAD	TCGA	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.1111
p.W114C	TCGA-68-A59J	LUSC	TCGA	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.0833
p.S1603N	TCGA-77-8144	LUSC	TCGA	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation blocking phosphorylation signal	0.6389
p.P1582A	TCGA-95-7562	LUAD	TCGA	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.1111
p.M96V	TCGA-AA-3713	COAD	TCGA	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.25
p.R1591Q	TCGA-AN-A0XU	BRCA	TCGA	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation altering degron motif	0.7329
p.R1591Q	SIDM00850	Gastric Carcinoma	GDSC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation altering degron motif	0.7329
p.S108F	TCGA-AX-A1CE	UCEC	TCGA	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.25
p.K1605N	TCGA-B7-5816	STAD	TCGA	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation substituting flanking lysine	0.25
p.P1582L	TCGA-BS-A0V4	UCEC	TCGA	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.1111
p.Q112H	TCGA-D5-5538	COAD	TCGA	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.1389
p.V99M	TCGA-DF-A2KU	UCEC	TCGA	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation altering degron motif	0.6097
p.S108Y	TCGA-EI-6917	READ	TCGA	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.25
p.L1599M	TCGA-EJ-7125	PRAD	TCGA	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.3056
p.T101I	TCGA-F5-6814	READ	TCGA	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation altering degron motif	0.7078
p.E103K	TCGA-FF-A7CX	DLBC	TCGA	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation altering degron motif	0.591
p.E103K	TCGA-FU-A40J	CESC	TCGA	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation altering degron motif	0.591
p.M95I	TCGA-K4-A54R	BLCA	TCGA	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.2222
p.M95I	SIDM01215	Ovarian Carcinoma	GDSC	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.2222
p.M95I	ACH-000542	Ovarian Cancer	CCLE	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.2222
p.I93M	TCGA-VQ-A8P2	STAD	TCGA	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.1667
p.E941Q	DO219007	BLCA	ICGC	LLLHQE	LIG_APCC_ABBA_1	938:943	Mutation altering degron motif	0.6744
p.A107V	DO1269	BRCA	ICGC	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.2778
p.E929K	DO222953	BTCA	ICGC	LLLHQE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.0833
p.D1599N	DO51612	CESC	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.3056
p.R108C	DO51734	COAD	ICGC	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.25
p.E941K	DO227549	COCA	ICGC	LLLHQE	LIG_APCC_ABBA_1	938:943	Mutation altering degron motif	0.7022
p.L938F	DO222884	COCA	ICGC	LLLHQE	LIG_APCC_ABBA_1	938:943	Mutation altering degron motif	0.587
p.H941N	DO222884	COCA	ICGC	LLLHQE	LIG_APCC_ABBA_1	938:943	Mutation altering degron motif	0.7423
p.A1607T	DO223149	ESCA	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.0833
p.E950D	DO233205	GACA	ICGC	LLLHQE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.1389
p.R108H	DO233647	GACA	ICGC	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.25
p.G102S	DO233766	GACA	ICGC	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation altering degron motif	0.6993
p.A1594S	DO228978	LICA	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation altering degron motif	0.7588
p.A1594S	DO229045	LICA	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation altering degron motif	0.7588
p.G951W	DO229029	LICA	ICGC	LLLHQE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.1111
p.A107S	DO229027	LICA	ICGC	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.2778
p.M103I	DO229006	LICA	ICGC	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation altering degron motif	0.7618
p.D110N	DO218937	LUAD	ICGC	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.1944
p.L1589Q	DO231036	LUSC	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.3056
p.E941D	DO45445	LUSC	ICGC	LLLHQE	LIG_APCC_ABBA_1	938:943	Mutation altering degron motif	0.6758
p.S1583F	DO222837	MELA	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation substituting flanking lysine	0.25
p.D944Y	DO232858	NACA	ICGC	LLLHQE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.3056
p.A1600D	DO232224	PBCA	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.2778
p.S1581L	DO51407	PRAD	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.0833
p.S1581L	DO43907	UCEC	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.0833
p.S1581L	DO41235	UCEC	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.0833
p.S1581L	DO41211	UCEC	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.0833
p.S1581L	DO41488	UCEC	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.0833
p.V1595M	DO51346	PRAD	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation altering degron motif	0.7208
p.E947G	DO220285	SARC	ICGC	LLLHQE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.2222
p.E947D	DO37571	SKCM	ICGC	LLLHQE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.2222
p.Q934K	DO37921	SKCM	ICGC	LLLHQE	LIG_APCC_ABBA_1	938:943	Mutation rewiring degron network	0.2222
p.A1593T	DO51301	SKCM	ICGC	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation altering degron motif	0.7139
p.L95M	DO42073	UCEC	ICGC	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.2222
p.P1581H	ACH-000872	Lung Cancer	CCLE	IRRKLAGLS	DEG_APCC_DBOX_1	1590:1598	Mutation rewiring degron network	0.0833
p.K928T	ACH-002023	Colon/Colorectal Cancer	CCLE	LLLHQE	LIG_APCC_ABBA_1	938:943	Mutation substituting flanking lysine	0.1667
p.H98R	ACH-002163	Breast Cancer	CCLE	VETPEGE	DEG_SCF_FBW7_2	99:105	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC180

UniProt ID: Q9P1Z9

Entrez ID: 100499483

Protein name: Coiled-coil domain-containing protein 180

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC180 in