DegronMD

Uniprot ID: Q9P1Z9

Source protein: Coiled-coil domain-containing protein 180

Source gene: CCDC180

Class: DEG_SCF_FBW7_2

Location: 99:105

E3 ligase: FBXW7

DEGRON score: 0.7671

ASA_SCORE: 86.7857

COIL: 0.7316

CONS_SCORE: 0.1397

DSS_SCORE: 0.591

HELIX: 0.0277

FCONS_SCORE: 1.0022

RIG_SCORE: 0.6991

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W114C	TCGA-68-A59J	LUSC	TCGA	VETPEGE	DEG_SCF_FBW7_2	0.0833
p.M96V	TCGA-AA-3713	COAD	TCGA	VETPEGE	DEG_SCF_FBW7_2	0.25
p.S108F	TCGA-AX-A1CE	UCEC	TCGA	VETPEGE	DEG_SCF_FBW7_2	0.25
p.Q112H	TCGA-D5-5538	COAD	TCGA	VETPEGE	DEG_SCF_FBW7_2	0.1389
p.V99M	TCGA-DF-A2KU	UCEC	TCGA	VETPEGE	DEG_SCF_FBW7_2	0.6097
p.S108Y	TCGA-EI-6917	READ	TCGA	VETPEGE	DEG_SCF_FBW7_2	0.25
p.T101I	TCGA-F5-6814	READ	TCGA	VETPEGE	DEG_SCF_FBW7_2	0.7078
p.E103K	TCGA-FF-A7CX	DLBC	TCGA	VETPEGE	DEG_SCF_FBW7_2	0.591
p.E103K	TCGA-FU-A40J	CESC	TCGA	VETPEGE	DEG_SCF_FBW7_2	0.591
p.M95I	TCGA-K4-A54R	BLCA	TCGA	VETPEGE	DEG_SCF_FBW7_2	0.2222
p.M95I	SIDM01215	Ovarian Carcinoma	GDSC	VETPEGE	DEG_SCF_FBW7_2	0.2222
p.M95I	ACH-000542	Ovarian Cancer	CCLE	VETPEGE	DEG_SCF_FBW7_2	0.2222
p.I93M	TCGA-VQ-A8P2	STAD	TCGA	VETPEGE	DEG_SCF_FBW7_2	0.1667
p.A107V	DO1269	BRCA	ICGC	VETPEGE	DEG_SCF_FBW7_2	0.2778
p.R108C	DO51734	COAD	ICGC	VETPEGE	DEG_SCF_FBW7_2	0.25
p.R108H	DO233647	GACA	ICGC	VETPEGE	DEG_SCF_FBW7_2	0.25
p.G102S	DO233766	GACA	ICGC	VETPEGE	DEG_SCF_FBW7_2	0.6993
p.A107S	DO229027	LICA	ICGC	VETPEGE	DEG_SCF_FBW7_2	0.2778
p.M103I	DO229006	LICA	ICGC	VETPEGE	DEG_SCF_FBW7_2	0.7618
p.D110N	DO218937	LUAD	ICGC	VETPEGE	DEG_SCF_FBW7_2	0.1944
p.L95M	DO42073	UCEC	ICGC	VETPEGE	DEG_SCF_FBW7_2	0.2222
p.H98R	ACH-002163	Breast Cancer	CCLE	VETPEGE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1Z9	Coiled-coil domain-containing protein 180	DEG_SCF_FBW7_2	99:105	VETPEGE	FBXW7	0.7671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons