DegronMD

Uniprot ID: Q9P1Z9

Source protein: Coiled-coil domain-containing protein 180

Source gene: CCDC180

Class: LIG_APCC_ABBA_1

Location: 938:943

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5757

ASA_SCORE: 91.55

COIL: 0.0603

CONS_SCORE: 0.5681

DSS_SCORE: 0.2065

HELIX: 0.9408

FCONS_SCORE: 1.1978

RIG_SCORE: 0.8031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E941Q	DO219007	BLCA	ICGC	LLLHQE	LIG_APCC_ABBA_1	0.6744
p.E929K	DO222953	BTCA	ICGC	LLLHQE	LIG_APCC_ABBA_1	0.0833
p.E941K	DO227549	COCA	ICGC	LLLHQE	LIG_APCC_ABBA_1	0.7022
p.L938F	DO222884	COCA	ICGC	LLLHQE	LIG_APCC_ABBA_1	0.587
p.H941N	DO222884	COCA	ICGC	LLLHQE	LIG_APCC_ABBA_1	0.7423
p.E950D	DO233205	GACA	ICGC	LLLHQE	LIG_APCC_ABBA_1	0.1389
p.G951W	DO229029	LICA	ICGC	LLLHQE	LIG_APCC_ABBA_1	0.1111
p.E941D	DO45445	LUSC	ICGC	LLLHQE	LIG_APCC_ABBA_1	0.6758
p.D944Y	DO232858	NACA	ICGC	LLLHQE	LIG_APCC_ABBA_1	0.3056
p.E947G	DO220285	SARC	ICGC	LLLHQE	LIG_APCC_ABBA_1	0.2222
p.E947D	DO37571	SKCM	ICGC	LLLHQE	LIG_APCC_ABBA_1	0.2222
p.Q934K	DO37921	SKCM	ICGC	LLLHQE	LIG_APCC_ABBA_1	0.2222
p.K928T	ACH-002023	Colon/Colorectal Cancer	CCLE	LLLHQE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1Z9	Coiled-coil domain-containing protein 180	LIG_APCC_ABBA_1	938:943	LLLHQE	APC,CDC20,FZR1	0.5757	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons