DegronMD

Uniprot ID: Q9C0J1

Source protein: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4

Source gene: B3GNT4

Class: DEG_APCC_DBOX_1

Location: 330:338

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7037

ASA_SCORE: 81.1111

COIL: 0.8849

CONS_SCORE: 0.3977

DSS_SCORE: 0.0471

HELIX: 0.0341

FCONS_SCORE: 0.805

RIG_SCORE: 0.8109

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A323V	TCGA-55-7573	LUAD	TCGA	IRRPLDPLD	DEG_APCC_DBOX_1	0.1389
p.W335L	DO1071	BRCA	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	0.7015
p.H324Y	DO5507	BRCA	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	0.1667
p.R325H	DO7776	COAD	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	0.1944
p.R325C	DO48682	LIRI	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	0.1944
p.L329I	DO37695	SKCM	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	0.3056
p.E330K	DO37567	SKCM	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	0.7022
p.E330K	DO47459	SKCM	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	0.7022
p.E330K	DO47777	STAD	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	0.7022
p.A336T	DO219773	UCEC	ICGC	IRRPLDPLD	DEG_APCC_DBOX_1	0.7139
p.R331Q	SIDM00535	Chondrosarcoma	GDSC	IRRPLDPLD	DEG_APCC_DBOX_1	0.7329
p.R331Q	SIDM00493	Other Solid Cancers	GDSC	IRRPLDPLD	DEG_APCC_DBOX_1	0.7329
p.A323S	SIDM00255	Neuroblastoma	GDSC	IRRPLDPLD	DEG_APCC_DBOX_1	0.1389
p.A323S	NB17	autonomic_ganglia	COSMIC	IRRPLDPLD	DEG_APCC_DBOX_1	0.1389
p.F325L	SIDM00965	Small Cell Lung Carcinoma	GDSC	IRRPLDPLD	DEG_APCC_DBOX_1	0.1944
p.R332W	SIDM00881	Breast Carcinoma	GDSC	IRRPLDPLD	DEG_APCC_DBOX_1	0.7523
p.R332W	HCC1428	breast	COSMIC	IRRPLDPLD	DEG_APCC_DBOX_1	0.7523
p.H324Q	ACH-001618	Leukemia	CCLE	IRRPLDPLD	DEG_APCC_DBOX_1	0.1667
p.C340R	CAL-62	thyroid	COSMIC	IRRPLDPLD	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0J1	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4	DEG_APCC_DBOX_1	330:338	IRRPLDPLD	APC,CDC20,FZR1	0.7037	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons